韩 鸿宾
北京大学第三医院放射科,磁共振成像与技术北京市重点实验室,北京 100191,
Beijing Key Laboratory of Magnetic Resonance Imaging Equipment and Technique, Beijing 100191, China
北京大学第三医院放射科,磁共振成像与技术北京市重点实验室,北京 100191,
Beijing Key Laboratory of Magnetic Resonance Imaging Equipment and Technique, Beijing 100191, China
△,e-mail,
During 1993-2003, when studying the early diagnosis of cerebral ischemic stroke and the quantitative analysis of the blood brain barrier permeability, a parameter of extracellular space was derived from the raw data of permeability of blood brain barrier. Dr. Han realized that the brain extracellular space is an unknown space to neuroscience and decided to explore the space since then. In 2004, Dr. Han proposed and established a novel method of measuring the brain extracellular space, magnetic resonance tracer based method to detect brain extracellular space, the measuring system was finally finished and got patented in 2013. In 2015, by using the newly developed method, Dr. Han and his group discovered that a new division system in the brain: the brain interstitial fluid drains in a regionalized extracellular space system. Based on the above findings, Dr. Han and his fellows designed and developed a new drug delivery method, by which the drug was delivered
via
brain extracellular space and bypass the obstacle of the blood-brain barrier as it does with the routine oral or intravenous administration. In 2017, the barrier structure to impede the brain interstitial fluid drainage was identified as the compact fiber fascicles in the deep brain, and a new hypothesis of local brain homeostasis within each extracellular space divisions was therefore proposed and published the cover story in the journal of
Progress in Neurobiology
. In pre-sent, new method and discoveries have been applied in several frontier fields such as neuroscience, pharmacy, aerospace, artificial intelligence, as well as tumor therapy.
