Pharmacometrics，developed from the conventional pharmacokinetics，is the science of applying mathematical and statistical methods to characterize，understand，and predict a drug′s pharmacokinetic，pharmacodynamic，and biomarker-outcome behaviors.Pharmacometrics has been widely valued for its utility of modeling and simulation in drug research and development，therapeutic drug monitoring and individualized therapy.This paper reviewed the advances of pharmacometrics employed in new drug research and development and therapeutic drug monitoring both at home and abroad.

尚德为,王曦培,邓晨辉,毕姗姗,管 峥,周田彦,卢 炜.定量药理学在新药研发及临床治疗药物监测方面的应用[J].中国药科大学学报,2010,41(1):91-96.
Cite：. Application of pharmacometrics in drug development and therapeutic drug monitoring[J]. J China Pharm Univ,2010,41(1):91-96.