北京大学国际癌症研究院、北京大学
-
云南白药国际医学研究中心、北京大学医学技术研究院、北京大学跨学部生物医学工程系研究员、博士生导师。主要从事生物材料与药物递送研究，在国际上率先提出了蛋白质
-
高分子精准偶联的概念，发展了定点原位聚合、类弹性蛋白多肽融合等新型蛋白质
-
高分子偶联技术，发明了仿生智能型蛋白质
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高分子偶联物、抗体
-
高分子
-
药物偶联物、蛋白质
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药物偶联物等新型生物偶联物，发现了乏氧触发氧化胺高分子生物还原、类弹性蛋白多肽嵌合体靶向降解蛋白等新现象，并揭示了其分子机制，为新型大分子药物和生物材料的设计、研发和临床转化提供了新思路。
在
PNAS
、
JACS
、
Angew
、
AM
等上发表了近
60
篇
SCI
论文。已有
5
项国内外发明专利转让于美国公司
Gateway Biotech, Inc.
和中山华梓生物科技有限公司，其中治疗恶性脑瘤的温敏干扰素即将申报临床一期。获
Bayer Investigator Award
、
Janssen Investigator Award
等奖励。主持或参与了
6
项国自然重大、重点和面上等科研项目，并任国自然、科技部
“十四五”及国家中长期科技发展战略规划编写组专家。
1. Sanke Zhang, Yuanzi Sun, Longshuai Zhang, Fan Zhang,
Weiping Gao
*. Thermoresponsive polypeptide fused L-asparaginase with mitigated immunogenicity and enhanced efficacy in treating hematologic malignancies.
Adv. Sci.
2023
, 2300469.
2. Fei Duan, Wei Jin, Tong Zhang, Yuanzi Sun, Xuliang Deng*
，
Weiping Gao*
,
. Thermo-pH-sensitive polymer conjugated glucose oxidase for tumour-selective starvation-oxidation-immune therapy.
Adv. Mater.
2023
,
adma.202209765
3. Longshuai Zhang, Jiawei Sun, Wenchao Huang, Sanke Zhang, Xuliang Deng,
Weiping Gao
*
. Hypoxia-triggered bioreduction of poly(
N
-oxide)-drug conjugates enhances tumour penetration and antitumour efficacy.
J. Am. Chem. Soc.
2023,
145,
1707−1713.
4. Tong Zhang, Wei An, Jiawei Sun, Fei Duan, Zeyu Shao, Fan Zhang, Ting Jiang
*
, Xuliang Deng*, Cyrille Boyer*,
Weiping Gao*
. N-Terminal Lysozyme Conjugation to a Cationic Polymer Enhances Antimicrobial Activity and Overcomes Antimicrobial Resistance.
Nano Lett.
2022
,
22
, 8294
−
8303.
5. Like Gong, Zhaoying Yang, Fan Zhang,
Weiping Gao*
. Cytokine conjugates to elastin-like polypeptides.
Adv. Drug Deliver. Rev.
2022
,
190
, 114541.
6. Xinyu Liu,
Weiping Gao*
.
Precision conjugation: an emerging tool for generating protein
‐
polymer conjugates
.
Angew. Chem. Int. Ed.
2021
,
60
, 11024-11035.
7. Ping Liang, Guihuai Wang, Xinyu Liu, Zhuoran Wang, Jing Wang,
Weiping Gao
*
.
Spatiotemporal combination of thermosensitive polypeptide fused interferon and temozolomide for post-surgical glioblastoma immunochemotherapy.
Biomaterials
2021
,
264
, 120447.
8. Zhuoran Wang, Jianwen Guo, Jiawei Sun, Ping Liang, Yan Wei, Xuliang Deng,
Weiping Gao
*.
Thermoresponsive and protease-cleavable interferon-polypeptide conjugates with spatiotemporally-programmed two-step release kinetics for tumor therapy.
Adv. Sci.
2019
,
6
，
1900586
.
9. Xinyu Liu, Mengmeng Sun, Jiawei Sun, Jin Hu, Zhuoran Wang, Jianwen Guo,
Weiping Gao
*
.
Polymerization induced self-assembly of a site-specific interferon
a
-block copolymer conjugate into micelles with remarkably enhanced pharmacology.
J. Am. Chem. Soc.
2018,
140,
10435-10438.
10. Jin Hu, Guilin Wang, Xinyu Liu,
Weiping Gao
*
. Enhancing pharmacokinetics, tumor accumulation and antitumor efficacy by elastin-like polypeptide fusion of interferon alpha.
Adv. Mater.
2015
,
27
, 7320-7324.
