（1） 生物药物/载体递送 （2） 智能/多功能纳米制剂技术 （3） 高端制剂研发与产业化

1、科研项目 （1）江苏省科技厅，江苏省自然科学基金社会发展项目，BE2023845，核酸疫苗纳米铝佐剂研发，2023-10至2026-09，100万元，在研，主持 （2）国家自然科学基金委员会，国家自然科学基金面上项目，81872817，构建“三元联动”重塑肿瘤免疫微环境的ATP超敏纳米凝胶用于胰腺癌化疗免疫联合治疗研究，2019-01至2022-12，55万元，结题，主持 （3）科技部，国家重大研发计划“纳米科技”重点专项，2017YFA0205405，肿瘤乏氧微环境相关纳米药物设计及规模化制备，2017-07至2022-06，650万，结题，主持 （4）国家自然科学基金委员会，国家自然科学基金面上项目，81373983，壳聚糖衍生物—微量元素－大黄素三元配位超分子肾靶向递药系统的研究，2014-01至2017-12，72万元，结题，主持 （5）国家自然科学基金委员会，国家自然科学基金面上项目，81573377，双功能糊精纳米凝胶作为microRNA载体用于高转移性胆管癌治疗的研究，2016-01至2019-12，54万元，结题，主持 （6）江苏省科技厅，江苏省自然科学基金杰出青年基金项目，BK20170028，逆转肿瘤转移与耐受的微环境响应型siRNA纳米药物的研究，2017-07至2020-06，100万，结题，主持 2、学术获奖 （1）2022/07，江苏省青年科技奖，排名1/1 （2）2021/07，Young Investigator Award of Controlled Release Society（国际控释协会青年科学家奖），排名：1/1 （3）2021/03，“教育部高等学校科学研究优秀成果奖（科学技术）自然科学奖”，一等奖，排名：3/9 （4）2018/02,“教育部高等学校科学研究优秀成果奖（科学技术）技术发明奖”，一等奖，排名：4/6

1.Feiran Zhang, Jingwen Dong, Kan Huang, Bowen Duan, Chenzi Li, Ruoxi Yang, Jing Li, Feng Zhi,* Zhanwei Zhou,* and Minjie Sun*. “Dominolike” Barriers Elimination with an Intratumoral Adenosine-Triphosphate Supersensitive Nanogel to Enhance Cancer Chemoimmunotherapy. ACS Nano. 2023, 17, 18805−18817 2.Xue Yang, Jiayi Bian, Zheng Wang, Mengning He, Ying Yang, Quanhao Li, Xinping Luo, Zhanwei Zhou, Jing Li, Shenghong Ju,* and Minjie Sun*. A Bio-Liposome Activating Natural Killer Cell by Illuminating Tumor Homogenization Antigen Properties. Adv. Sci. 2023, 2205449 3.Zhanwei Zhou, Huan Liang, Ruoxi Yang, Ying Yang, Jingwen Dong, Yongxiang Di, Minjie Sun*. Glutathione Depletion-Induced Activation of Dimersomes for Potentiating the Ferroptosis and Immunotherapy of “Cold” Tumor. Angew. Chem. Int. Ed. 2022, 61: e202202843. (IF:16.823) 4. Jingwen Dong, Chenfei Zhu, Feiran Zhang, Zhanwei Zhou*, Minjie Sun*“Attractive/adhesion force” dual-regulatory nanogels capable of CXCR4 antagonism and autophagy inhibition for the treatment of metastatic breast cancer. J. Controlled Release. 2022, 341:892–903. (IF:11.467) 5. Lianghan Zhu, Zhaoting Li, Ning Liu, Honghao Sun, Yixin Wang, and Minjie Sun*. Dynamically Deformable Protein Delivery Strategy Disassembles Neutrophil Extracellular Traps to Prevent Liver Metastasis. Adv. Funct. Mater. 2021, 31:2105089. (IF:19.924) 6. Xinping Luo, Dehong Hu, Duyang Gao, Yuenan Wang, Xinhua Chen, Xin Liu, Hairong Zheng, Minjie Sun*, and Zonghai Sheng*. Metabolizable Near-Infrared-II Nanoprobes for Dynamic Imaging of Deep-Seated Tumor-Associated Macrophages in Pancreatic Cancer. ACS Nano. 2021, 15:10010−10024. (IF 18.027) 7. Xue Yang, Ying Yang, Jiayi Bian, Jiajia Wei, Zheng Wang, Zhanwei Zhou, Zhaoting Li, Minjie Sun*. Converting primary tumor towards an in situ STING-activating vaccine via a biomimetic nanoplatform against recurrent and metastatic tumors. Nano Today. 2021, 38:101109. (IF:18.922) 8. Zhaoting Li, Lianghan Zhu, Honghao Sun, Yuexin Shen, Dandan Hu, Wenhao Wu, Yixin Wang, Chenggen Qian, Minjie Sun*. Fluorine assembly nanocluster breaks the shackles of immunosuppression to turn the cold tumor hot. PNAS (Proceedings of the National Academy of Sciences of USA). 2020, 117(52): 32962–32969. (IF:12.779). 9. Zhanwei Zhou, Hui Wu, Ruoxi Yang, Alan Xu, Qingyan Zhang, Jingwen Dong, Chenggen Qian, Minjie Sun*. GSH depletion liposome adjuvant for augmenting the photothermal immunotherapy of breast cancer. Sci. Adv. 2020, 6(36): eabc4373. (IF:14.957) 10. Zhaoting Li, Yixin Wang, Yuexin Shen, Chenggen Qian, David Oupicky, Minjie Sun*. Targeting pulmonary tumor microenvironment with CXCR4-inhibiting nanocomplex to enhance anti-PD-L1 immunotherapy. Sci. Adv. 2020, 6(20): eaaz9240. (IF:14.957)

孙敏捷教授 周占威副研究员