School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.
Centro de Investigaciones Educativas, Universidad del Valle de Guatemala, Guatemala, Guatemala.
Centro de Estudios en Informática Aplicada, Universidad del Valle de Guatemala, Guatemala, Guatemala.
Great Ormond Street Institute of Child Health, University College London, London, UK.
目的本研究的目的是研究成年前身体发育与64至76岁年龄段的五个结局之间的关系：体重，体重指数（BMI），估计的体脂百分比，握力和死亡率。方法对身高，体重，身高，体重和体重的大小，时间和强度（峰值生长速度，例如cm /年）的40 484名危地马拉3至19岁个体的平移和旋转叠加（SITAR）生长曲线进行建模。 BMI和握力。使用线性和二元logistic回归测试了危地马拉人的高社会经济地位（SES）随访样本，测试了SITAR参数与老年结局之间的关联，其中50例在重新测量时年龄为64-76岁，而45例在死亡之前死亡。 2017年。结果SITAR模型解释了每种结果的69％至98％的方差，其中高度最精确。随访样本中在20岁之前具有较高BMI的个体在64岁时具有较高的估计体脂（B = 1.4 CI -0.02-2.8）和BMI（B = 1.2，CI 0.2-2.2）到76年 那些在20岁之前身高增长较慢但体重和BMI增长较快的人的BMI和体脂更高。结论这些发现突出了生命周期观点对健康和死亡风险的重要性。童年时期导致成年前生长变化的接触可能是更好地了解老年人健康和死亡风险的关键。8）和BMI（B = 1.2，CI 0.2-2.2），年龄在64至76岁之间。那些在20岁之前身高增长较慢但体重和BMI增长较快的人的BMI和体脂更高。结论这些发现突出了生命周期观点对健康和死亡风险的重要性。童年时期导致成年前生长变化的接触可能是更好地了解老年人健康和死亡风险的关键。8）和BMI（B = 1.2，CI 0.2-2.2），年龄在64至76岁之间。那些在20岁之前身高增长较慢但体重和BMI增长较快的人的BMI和体脂更高。结论这些发现突出了生命周期观点对健康和死亡风险的重要性。童年时期导致成年前生长变化的接触可能是更好地了解老年人健康和死亡风险的关键。
OBJECTIVES
The objective of this study was to investigate the association between physical growth in preadult life with five outcomes at ages 64 to 76: weight, body mass index (BMI), estimated body fat percentage, hand grip strength, and mortality.
METHODS
Super-imposition by translation and rotation (SITAR) growth curves of 40 484 Guatemalan individuals aged 3 to 19 years were modeled for the parameters of size, timing and intensity (peak growth velocity, eg, cm/year) of height, weight, BMI, and grip strength. Associations between the SITAR parameters and old age outcomes were tested using linear and binary logistic regression for a follow-up sample of high socioeconomic status (SES) Guatemalans, of whom 50 were aged 64 to 76 years at re-measurement and 45 died prior to the year 2017.
RESULTS
SITAR models explained 69% to 98% of the variance in each outcome, with height the most precise. Individuals in the follow-up sample who had a higher BMI before the age of 20 years had higher estimated body fat (B = 1.4 CI -0.02-2.8) and BMI (B = 1.2, CI 0.2-2.2) at the ages of 64 to 76 years. Those who grew slower in height but faster in weight and BMI before the age of 20 years had higher BMI and body fat later in life.
CONCLUSIONS
These findings highlight the importance of a life course perspective on health and mortality risk. Childhood exposures leading to variation in preadult growth may be key to better understanding health and mortality risks in old age.
