中国科学院精密测量科学与技术创新研究院（以下简称精密测量院）是由中国科学院武汉物理与数学研究所（始建于1958年）、中国科学院测量与地球物理研究所（始建于1957年）融合组建而成，是湖北省首个中国科学院创新研究院。
回望来时路，峥嵘六十载。在方俊、王天眷、张承修、李钧、李国平、丁夏畦、许厚泽、叶朝辉等老一辈科学家的带领下，精密测量院历经几代科技工作者的辛勤努力和开拓创新，解决了一系列事关国家全局的重大科...
精密测量院立足精密测量科学与技术创新，面向国家的重大战略需求，发挥多学科交叉优势，开展原子频标与精密测量物理、大地测量和地球物理、综合定位导航授时、脑科学与重大疾病以及多学科交叉的数学计算等研究，促进以原子频标、原子干涉、核磁共振、重力测量、地震探测等精密测量技术为核心的学科发展，形成精密原子、精密分子、精密地球三...
第一作者论文
1. J. Wang, H.Y. Du, L.H. Jiang, X.X. Ma, R.A. de Graaf, K.L. Behar, G.F. Mason, Oxidation of ethanol in the rat brain and effects associated with chronic ethanol exposure, P Natl Acad Sci USA, 110 (2013) 14444-14449.
2. J. Wang, H.Y. Du, X.X. Ma, B. Pittman, L. Castracane, T.K. Li, K.L. Behar, G.F. Mason, Metabolic products of [2-C-13]ethanol in the rat brain after chronic ethanol exposure, J Neurochem, 127 (2013) 353-364.
3. J. Wang, L.H. Jiang, H.Y. Du, K.L. Behar, T.K. Li, G.F. Mason, Ethanol as Metabolic Precursor and Fuel for the Brain, Alcohol Clin Exp Res, 37 (2013) 254a-254a. Alcoholism-Clinical and Experimental Research
4. J. Wang, P.C. Nicholas, D. Kim, L.H. Jiang, L. Castracane, J.M. Macdonald, F.T. Crews, G.F. Mason, Metabolic Products of [1-13c] Ethanol in the Awake Rat Brain, Alcohol Clin Exp Res, 36 (2012) 83a-83a.
5. J. Wang, L.H. Jiang, H.Y. Du, G.F. Mason, An Ethanol Vapor Chamber for Small Animals, Alcohol Clin Exp Res, 36 (2012) 29a-29a.
6. J. Wang, L.H. Jiang, H.Y. Du, G.F. Mason, An ethanol vapor chamber system for small animals, J Neurosci Meth, 208 (2012) 79-85.
7. J. Wang, L.H. Jiang, Y.F. Jiang, X.X. Ma, G.M.I. Chowdhury, G.F. Mason, Regional metabolite levels and turnover in the awake rat brain under the influence of nicotine, J Neurochem, 113 (2010) 1447-1458.
8. J. Wang, H.X. Liu, S. Qin, X.J. Yao, M.C. Liu, Z.D. Hu, B.T. Fan, Study on the structure-activity relationship of new anti-HIV nucleoside derivatives based on the support vector machine method, Qsar Comb Sci, 26 (2007) 161-172.
9. J. Wang, H. Du, X. Yao, Z. Hu, Using classification structure pharmacokinetic relationship (SCPR) method to predict drug bioavailability based on grid-search support vector machine, Anal Chim Acta, 601 (2007) 156-163.
10. J. Wang, H. Du, H. Liu, X. Yao, Z. Hu, B. Fan, Prediction of surface tension for common compounds based on novel methods using heuristic method and support vector machine, Talanta, 73 (2007) 147-156.
11. J. Wang, H.X. Liu, H.Z. Si, X.J. Yao, M.C. Liu, Z.D. Hu, Prediction of the power rotation of the amino acid based on the quantitative structure-property relationship method, Chinese J Anal Chem, 34 (2006) 1759-1762.
通讯作者论文
33. Mei Li#, Zhuang Liu#, Yang Wu, Ning Zheng, Xiaodong Liu, Aoling Cai, Danhao Zheng, Jinpiao Zhu, Jinfeng Wu, Lingling Xu, Xihai Li, Ling-Qiang Zhu, Anne Manyande, Fuqiang Xu*, Jie Wang*, In vivo Imaging of Astrocytes in the Whole Brain with Engineered AAVs and Diffusion Weighted Magnetic Resonance Imaging, Molecular Psychiatry, Accepted (中科院1区；JCR1区；IF=15.992，封面文章)
32. Yuanyuan Fang#, Chang Chen#, Qi Zhong, Lirong Wang, Zhu Gui, Jinpiao Zhu, Anne Manyande, Fuqiang Xu, Jie Wang*, Zongze Zhang*, Cerebral Glucose Metabolism Is Affected by Chronic Pain-Mediated Cognitive Impairment in Adolescent Rats, Molecular Neurobiology, Accepted, (中科院2区；JCR1区；IF=5.59)
31. Tian Tian#, Jinfeng Wu#, Tao Chen, Jia Li, Su Yan, Yiran Zhou, Xiaolong Peng, Yuanhao Li, Ning Zheng, Aoling Cai, Qin Ning, Hongbing Xiang, Fuqiang Xu, Yuanyuan Qin*, Wenzhen Zhu*, Jie Wang*, Long-term follow-up studies for dynamic brain changes in recovered COVID-19 patients without neurological manifestations. JCI insight, 2022;7(4):e155827 (中科院1区；JCR1区；IF=8.315，封面文章)
30. Yuanyuan Qin#; Jinfeng Wu#; Tao Chen#; Jia Li; Guiling Zhang; Di Wu; Yiran Zhou; Ning Zheng; Aoling Cai; Qin Ning; Anne Manyande; Fuqiang Xu; Jie Wang*; Wenzhen Zhu*; Long-term micro-structure and cerebral blood flow changes in patients recovered from COVID-19 without neurological manifestations, Journal of Clinical Investigation, 2021, 131(8):e147329 . (中科院1区；JCR1区；IF=14.808，高被引论文，获国际同行专家述评)
29. Ning Zheng（郑宁）#; Mei Li（李梅）#; Yang Wu; Challika Kaewborisuth; Zhen Li; Zhu Gui; Jinfeng Wu; Aoling Cai; Kangguang Lin; Kuan-Pin Su; Hongbing Xiang; Xuebi Tian; Anne Manyande, Fuqiang Xu; Jie Wang（王杰）*; A novel technology for in vivo detection of cell type-specific 1 neural connection with AQP1-encoding rAAV2-retro vector and metal-free MRI, Neuroimage, 258 (2022) 119402.（中科院1区；JCR1区；IF=6.556）
28. Meimei Guo（郭美美硕士）#; Yuxiang Wu（吴钰祥）#; Danhao Zheng; Lei Chen; Bingrui Xiong; Jinfeng Wu; Ke Li; Li Wang; Kangguang Lin; Zongze Zhang; Anne Manyande; Fuqiang Xu; Jie Wang（王杰）*; Mian Peng（彭勉）*, Preoperative acute sleep deprivation causes postoperative pain hypersensitivity and abnormal cerebral function, Neuroscience Bulletin, Accepted. （中科院2区；JCR2区；IF=5.203） ——合作单位：武汉大学中南医院彭勉教授，联培学生郭美美
27. Zhen Li(李珍)，Tianning Sun，Zhigang He，Zhixiao Li，Wencui Zhang，Jie Wang（王杰），Hongbing Xiang（项红兵），SCFAs ameliorate chronic postsurgical pain-related cognition dysfunction via the ACSS2-HAD in rats，Molecular neurobiology（Accepted）——合作单位：华中科技大学同济医院项红兵教授，联培学生李珍
26. Dandan Sun#; Huiling Guo#; Fay Y. Womer; Jingyu Yang; Jingwei Tang; Juan Liu; Yue Zhu; Jia Duan; Zhengwu Peng; Huaning Wang; Qingrong Tan; Qiwen Zhu; Yange Wei; Yanbo Zhang; Yanqing Tang; Xizhe Zhang*; Fuqiang Xu*; Jie Wang*; Fei Wang*, Frontal-posterior functional imbalance and aberrant function developmental patterns in schizophrenia. Transl Psychiat 11(1), (2021), 495. (中科院1区；JCR1区；IF=6.222)
25. Meng-Yuan Chen#; Zhu Gui#; Ke-Ke Chen; Jiang-Hui Ding; Jin-Gang He; Jun Xiong; Jia-Le Li; Jie Wang*; Bi-Feng Yuan*; Yu-Qi Feng, Adolescent alcohol exposure alters DNA and RNA modifications in peripheral blood by liquid chromatography-tandem mass spectrometry analysis; Chinese Chemical Letters, 2021, Accepted. (中科院2区；JCR1区；IF=6.779)
24. Ying Liu, Shuang Li, Bo Rao, Ning Zheng, Jie Wang*, Linlin Bi*, Haibo Xu*, Distinct hypothalamic paraventricular nucleus inputs to the cingulate cortex and paraventricular thalamic nucleus modulate anxiety and arousal. Frontiers in Pharmacology, (2022) 13: 814623 (中科院2区；JCR1区；IF=5.811).
23. Lei Chen#; Shuang Li#; Ying Zhou; Taotao Liu; Aoling Cai; Zongze Zhang; Fuqiang Xu; Ane Manyande; Jie Wang*; Mian Peng*; Neuronal mechanisms of adenosine A2A receptors in the loss of consciousness induced by propofol general anesthesia with functional magnetic resonance imaging, Journal of Neurochemistry, 2021, 156(6): 1020-1032. (中科院2区；JCR1区；IF=5.372)
22. Aoling Cai#; Ning Zheng#; Garth J. Thompson; Yang Wu; Binbin Nie; Kunzhang Lin; Peng Su; Jinfeng Wu; Anne Manyande; Ling-Qiang Zhu; Jie Wang*; Fuqiang Xu*; Longitudinal neural connection detection using a Ferritin-encoding Adeno-associated virus vector and in vivo MRI method, Human Brain Mapping, 2021, 42: 5010–5022.. (中科院2区；JCR1区；IF=5.038)
21. Hongying Du, Jin Zhang, Siqi Wang, Anne Manyande, Jie Wang*, Effect of high-intensity ultrasonic treatment on the physicochemical, structural, rheological, behavioral, and foaming properties of pumpkin (Cucurbita moschata Duch.)-seed protein isolates. LWT, 155 (2022) 112952 (中科院1区；JCR1区；IF=4.952)
20. Meimei Guo; Yuanyuan Fang; Jinpiao Zhu; Chang Chen; Zongze Zhang; Xuebi Tian; Hongbing Xiang; Anne Manyande; Mojtaba Ehsanifar; Ahmad Jonidi Jafari; Fuqiang Xu; Jie Wang*; Mian Peng*; Investigation of metabolic kinetics in different brain regions of awake rats using the [1H-13C]-NMR technique, Journal of Pharmaceutical and Biomedical Analysis, 2021, 204: 114240. (中科院2区；JCR2区；IF=3.935)
19. Danhao Zheng#; Zhao Li#; Shuang Li; Xihai Li; Ghulam Mustafa Kamal; Chaoyang Liu; Anne Manyande; Fuqiang Xu; Qingjia Bao*; Jie Wang*; Identification of metabolic kinetic patterns in different brain regions using metabolomics methods coupled with various discriminant approaches, Journal of Pharmaceutical and Biomedical Analysis, 2021, 198: 114027. (中科院2区；JCR2区；IF=3.935)
18. Yue Liu#; Binbin Nie#; Taotao Liu; Ning Zheng; Zeyuan Liu; Baoci Shan; Lihong Jiang; Anne Manyande; Xihai Li; Fuqiang Xu*; Jie Wang*; Variations of Brain Functional Connectivity in Alcohol-Preferring and Non-Preferring Rats with Consecutive Alcohol Training or Acute Alcohol Administration, Brain Sci. 2021, 11, 1474. (中科院3区；JCR3区；IF=3.394)
17. Yue Liu#; Shusheng Yang#; Erli Cai#; Li Lin; Peng Zeng; Binbin Nie; Fuqiang Xu; Qing Tian*; Jie Wang*; Functions of lactate in the brain of rat with intracerebral hemorrhage evaluated with MRI/MRS and in vitro approaches, CNS Neuroscience & Therapeutics, 2020 26: 1031-1044. (中科院2区；JCR1区；IF=5.243
16. Xiaoping Rao; Jie Wang*, Neuronal Network Dissection with Neurotropic Virus Tracing. Neurosci. Bull. 2020, 36, (3), 199-201. (中科院2区；JCR2区；IF=5.203)
15. Taotao Liu; Zhengqian Li; Jindan He; Ning Yang; Dengyang Han; Yue Li; Xuebi Tian; Huili Liu; Anne Manyande; Hongbing Xiang; Fuqiang Xu; Jie Wang*; Xiangyang Guo*, Regional Metabolic Patterns of Abnormal Postoperative Behavioral Performance in Aged Mice Assessed by H-1-NMR Dynamic Mapping Method. Neurosci. Bull. 2020, 36, (1), 25-38. (中科院2区；JCR2区；IF=5.203
14. Liang Wu#; Zhanfeng Niu#; Xulei Hu; Huili Liu; Shuang Li; Lei Chen; Danhao Zheng; Zhuang Liu; Taotao Liu; Fuqiang Xu; Anne Manyande; Jie Wang*; Hechun Xia*; Regional cerebral metabolic levels and turnover of the awake rats after acute or chronic spinal cord injury. FASEB Journal, 2020, 34: 10547-10559. (中科院2区；JCR1区；IF=5.192
13. Wenchang Zhou#; Aoling Cai#; Binbin Nie#; Wen Zhang; Ting Yang; Ning Zheng; Anne Manyande; Xuxia Wang; Fuqiang Xu; Xuebi Tian*; Jie Wang*; Investigation of robust visual reaction and functional connectivity in the rat brain induced by rocuronium bromide with functional MRI, American Journal of Translational Research, 2020, 12: 2396-2408. (中科院3区；JCR2区；IF=4.06)
12. T. Hu; Q. F. Zhu; Y. N. Hu; G. M. Kamal; Y. Q. Feng; A. Manyande; J. Wang*; F. Q. Xu*; Qualitative and Quantitative Analysis of Regional Cerebral Free Fatty Acids in Rats Using the Stable Isotope Labeling Liquid Chromatography-Mass Spectrometry Method, Molecules, 2020, 25. (中科院3区；JCR2区；IF=4.412)
11. Jingyu Yang, Huiling Guo, Dandan Sun, Jia Duan, Xiaoping Rao, Fuqiang Xu, Anne Manyande, Jie Wang*, Fei Wang*, Brain metabolite alterations in a schizophrenia rat model evaluated by proton nuclear magnetic resonance approaches, American Journal of Translational Research, 2019;11(9):5919-5931. (中科院3区；JCR2区；IF=4.06)
10. Cheng Huang1, JieWang1, NingWang, Feng Du,Wei Xiong, Junchao Qian, Kai Zhong, Aoling Cai, Shijin Xu, Jun Huang, Xueying Cheng, Shufang He, Ye Zhang, Effect of myocardial ischemic preconditioning on ischemia-reperfusion stimulation-induced activation in rat thoracic spinal cord with functional MRI, International Journal of Cardiology 285 (2019) 59–64. (中科院2区；JCR2区；IF=4.164)
9. Hongying Du1,*,y, Shuang Li1, Yingfeng Zhang, Huiling Guo, Liang Wu, Huili Liu, Anne Manyande, Fuqiang Xu, and Jie Wang*, NMR Based Metabolomics Comparison of Dierent Blood Sampling Techniques in Awake and Anesthetized Rats, Molecules 2019, 24, 2542 (中科院3区；JCR2区；IF=4.412)
8. N. Zheng1, P. Su1, Y. Liu, H. Wang, B. Nie, X. Fang, Y. Xu, K. Lin, P. Lv, X. He, Y. Guo, B. Shan, A. Manyande, J. Wang*, F. Xu*, Detection of neural connections with ex vivo MRI using a ferritin-encoding trans-synaptic virus, NeuroImage, 197 (2019) 133-142 (中科院1区；JCR1区；IF=6.556)
7. Jie Wang1, *, Hao-Long Zeng1, Hongying Du, Zeyuan Liu, Ji Cheng, Taotao Liu, Ting Hu, Ghulam Mustafa Kamal, Xihai Li, Huili Liu, Fuqiang Xu, Evaluation of metabolites extraction strategies for identifying different brain regions and their relationship with alcohol preference and gender difference using NMR metabolomics, Talanta, 2018, 179:369-376. (中科院2 区；JCR1区；IF=6.057)
6. H.L. Zeng1, Q. Yang1, H.Y. Du, H.J Li, Y. Shen, T.T. Liu, X. Chen, G.M. Kamal, Q. Guan, L.M. Cheng, J. Wang*, F.Q. Xu*, Proteomics and metabolomics analysis of hepatic mitochondrial metabolism in alcohol-preferring and non-preferring rats, Oncotarget, 2017, 8(60)102020-102032. (中科院未收录；JCR1区；IF=5.168)
5. T.T. Liu, Z.G. He, X.B. Tian, G.M. Kamal, Z.X. Li, Z.Y. Liu, H.L. Liu, F.Q. Xu, J. Wang*, H.B. Xiang*, Specific patterns of spinal metabolites underlying alpha-Me-5-HT-evoked pruritus compared with histamine and capsaicin assessed by proton nuclear magnetic resonance spectroscopy, BBA-Mol Basis Dis, 1863 (2017) 1222-1230. (中科院2区；JCR1区；IF=5.187)
4. Y. Liu, J. Cheng, H.L. Liu, Y.H. Deng, J. Wang*, F.Q. Xu*, NMRSpec: An integrated software package for processing and analyzing one dimensional nuclear magnetic resonance spectra, Chemometr Intell Lab, 162 (2017) 142-148. (中科院3区；JCR1区；IF=3.491)
3. R.X. Chen, Y.H. Deng, L. Yang, J. Wang*, F.Q. Xu*, Determination of Histamine by High-Performance Liquid Chromatography After Precolumn Derivatization with o-Phthalaldehyde-Sulfite, Journal of Chromatographic Science, 54 (2016) 547-553. (中科院4区；JCR4区；IF=1.618)
2. R.X. Chen, L. Wang, J. Wang*, F.Q. Xu*, Determination of Whiteners in Cosmetics by Microdialysis and High-Performance Liquid Chromatography, Analytical Letters, 48 (2015) 2159-2171. (中科院4区；JCR3区；IF=2.329)
1: R.X. Chen, Y.H. Deng, J. Yao, G.M. Kamal, J. Wang*, F.Q. Xu*, Assessment of Amino Acid Neurotransmitters in Rat Brain Microdialysis Samples by High-Performance Liquid Chromatography with Coulometric Detection, Journal of Liquid Chromatography & Related Technologies, 38 (2015) 1439-1447. (中科院4区；JCR4区；IF=1.312)
