陈宇-武汉大学生命科学学院

主要工作经历与任职情况

2016/11至今武汉大学生命科学学院，教授

2011.11-2016.10 武汉大学生命科学学院，副教授

2009.09-2011.10 武汉大学生命科学学院，讲师

主要社会兼职

2021，SCI期刊Viruses编辑

2021，SCI期刊Frontiers in Cellular and Infection Microbiology客座编辑

2021，湖北省生物工程学会理事

2020，科技部“十四五”重点专项指南编制专家

2020，生物医学领域新期刊Cell Insight编委

2015-至今，中国微生物学会病毒学专业委员会青年委员

主要科研奖励和个人荣誉

2020，荣获“湖北向上向善好青年”荣誉

2020，教育部“长江学者”特岗教授

2018，湖北省自然科学基金杰出青年基金获得者

本科生：《分子生物学实验》、通识课《病毒与生命》

主持课题项目

2021-2026，国家重点研发计划-生物大分子与微生物组专项，病毒复制合成的胞内膜结构建立机制，参与；

2021-2025，国家重点研发计划-基础科研条件与重大科学仪器设备研发专项，创新动物模型的应用及验证平台建设，子课题负责人；

2022-2025，国家自然科学基金面上项目，冠状病毒RNA m5C甲基化修饰机制与功能研究，主持；

2020-2022，国家自然科学基金-新冠病毒专项，新型冠状病毒2019-nCoV重要复制加帽酶的工作机制研究，主持；

2018-2020，国家科技重大专项-艾滋病和病毒性肝炎等重大传染病防治，新发突发病毒感染人的预警技术平台，参与；

2017-2020，国家自然科学基金面上项目，靶向冠状病毒关键功能蛋白的抑制剂设计及其抑制效应和机制研究，主持；

2018-2021，湖北省自然科学基金-杰出青年科学基金，病毒RNA甲基化修饰与免疫逃逸机制研究，主持。

发表的论文（#并列第一作者，*通讯作者）

1. Ma C ^# , Chen X ^# , Mei F ^# , Xiong Q, Liu Q, Dong L, Liu C, Zou W, Zhan F, Hu B, Liu Y, Liu F, Zhou L, Xu J, Jiang Y, Xu K, Cai K*, Chen Y *, Yan H*, Lan K* , Drastic decline in sera neutralization against SARS-CoV-2 Omicron variant in Wuhan COVID-19 convalescents. Emerg Microbes Infect. 2022;11(1):567-72.

2. Liu Q ^# , Xiong Q ^# , Mei F ^# , Ma C, Zhang Z, Hu B, Xu J, Jiang Y, Zhan F, Zhou S, Tao L, Chen X, Guo M, Wang X, Fang Y, Shen S, Liu Y, Liu F, Zhou L, Xu K, Ke C, Deng F, Cai K*, Yan H*, Chen Y *, Lan K*, Antibody neutralization to SARS-CoV-2 and variants after 1 year in Wuhan, China. Innovation (N Y) . 2022;3(1):100181.

3. Pan R ^# , Kindler E ^# , Cao L ^# , Zhou Y, Zhang Z, Liu Q, Ebert N, Züst R, Sun Y, Gorbalenya AE, Perlman S*, Thiel V*, Chen Y *, Guo D*,N7-Methylation of the Coronavirus RNA Cap Is Required for Maximal Virulence by Preventing Innate Immune Recognition. mBio. 2022;13(1):e0366221.

4. Yan H ^# , Jiao H ^# , Liu Q, Zhang Z, Xiong Q, Wang BJ, Wang X, Guo M, Wang LF, Lan K*, Chen Y *, Zhao H*, ACE2 receptor usage reveals variation in susceptibility to SARS-CoV and SARS-CoV-2 infection among bat species. Nature ecology & evolution . 2021;5(5):600-8. （ESI高被引论文）

5. Wang D ^# , Jiang A ^# , Feng J ^# , Li G ^# , Guo D ^# , Sajid M, Wu K, Zhang Q, Ponty Y, Will S, Liu F, Yu X, Li S, Liu Q, Yang XL, Guo M, Li X, Chen M, Shi ZL, Lan K*, Chen Y *, Zhou Y*,The SARS-CoV-2 subgenome landscape and its novel regulatory features. Molecular cell. 2021;81(10):2135-47.e5.

6. Zhang Z ^# , Liu Q ^# , Sun Y, Li J, Liu J, Pan R, Cao L, Chen X, Li Y, Zhang Y, Xu K, Guo D, Zhou L, Lan K, Chen Y *,Live attenuated coronavirus vaccines deficient in N7-Methyltransferase activity induce both humoral and cellular immune responses in mice. Emerg Microbes Infect. 2021;10(1):1626-37.

7. Xiong Y ^# , Liu Y ^# , Cao L ^# , Wang D ^# , Guo M, Jiang A, Guo D, Hu W, Yang J, Tang Z, Wu H, Lin Y, Zhang M, Zhang Q, Shi M, Liu Y, Zhou Y*, Lan K*, Chen Y *,Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients. Emerg Microbes Infect. 2020;9(1):761-70.（ESI高被引论文）

8. Suo T ^# , Liu X ^# , Feng J ^# , Guo M ^# , Hu W ^# , Guo D, Ullah H, Yang Y, Zhang Q, Wang X, Sajid M, Huang Z, Deng L, Chen T, Liu F, Xu K, Liu Y, Zhang Q, Liu Y, Xiong Y*, Chen G*, Lan K*, Chen Y *,ddPCR: a more accurate tool for SARS-CoV-2 detection in low viral load specimens. Emerg Microbes Infect . 2020 Dec;9(1):1259-1268.（ESI高被引论文）

9. Liu, Yuan ^# ; Ning, Zhi ^# *; Chen, Yu#* ; Guo, Ming#; Liu, Yingle; Gali,Nirmal Kumar; Sun, Li; Duan, Yusen; Cai, Jing; Westerdahl, Dane; Liu, Xinjin;Xu, Ke; Ho, Kin-fai* ; Kan, Haidong* ; Fu, Qingyan* ; Lan, Ke*, Aerodynamic analysis of SARS-CoV-2 in two Wuhan hospitals. Nature . 2020 Jun;582(7813):557-560.（ESI高被引论文）

10. Chen L ^# , Liu W ^# , Zhang Q ^# , Xu K, Ye G, Wu W, Sun Z, Liu F, Wu K, Zhong B, Mei Y, Zhang W, Chen Y *, Li Y*, Shi M*, Lan K*, Liu Y*,RNA based mNGS approach identifies a novel human coronavirus from two individual pneumonia cases in 2019 Wuhan outbreak. Emerg Microbes Infect. 2020 Feb 5;9(1):313-319.（ESI高被引论文）

11. Chen Y *, Liu Q, Guo D*,Emerging coronaviruses: Genome structure, replication, and pathogenesis. J Med Virol. 2020;92(4):418-23.(ESI高被引论文）

12. Liu X ^# , Feng J ^# , Zhang Q ^# , Guo D ^# , Zhang L, Suo T, Hu W, Guo M, Wang X, Huang Z, Xiong Y, Chen G*, Chen Y *, Lan K*,Analytical comparisons of SARS-COV-2 detection by qRT-PCR and ddPCR with multiple primer/probe sets. Emerg Microbes Infect. 2020;9(1):1175-9.

13. Cao L, Ji Y, Zeng L, Liu Q, Zhang Z, Guo S, Guo X, Tong Y, Zhao X, Li CM, Chen Y *, Guo D*, P200 family protein IFI204 negatively regulates type I interferon responses by targeting IRF7 in nucleus. PLoS Pathog. 2019;15(10):e1008079.

14. Gui M, Liu X, Guo D, Zhang Z, Yin CC*, Chen Y *, Xiang Y*,Electron microscopy studies of the coronavirus ribonucleoprotein complex. Protein & cell. 2017;8(3):219-24.

15. Chen Y *, Guo D*, Molecular mechanisms of coronavirus RNA capping and methylation. Virol Sin. 2016;31(1):3-11.

16. Cui L, Wang H, Ji Y, Yang J, Xu S, Huang X, Wang Z, Qin L, Tien P, Zhou X, Guo D*, Chen Y * . The Nucleocapsid Protein of Coronaviruses Acts as a Viral Suppressor of RNA Silencing in Mammalian Cells. J Virol. 2015;89(17):9029-43.

17. Liu X ^# , Hao R ^# , Chen S, Guo D, Chen Y * . Inhibition of hepatitis B virus by the CRISPR/Cas9 system via targeting the conserved regions of the viral genome. The Journal of general virology. 2015;96(8):2252-2261.

18. Wang Y ^# , Sun Y ^# , Wu A, Xu S, Pan R, Zeng C, Jin X, Ge X, Shi Z, Ahola T, Chen Y * , Guo D*. Coronavirus nsp10/nsp16 Methyltransferase Can Be Targeted by nsp10-Derived Peptide In Vitro and In Vivo To Reduce Replication and Pathogenesis. J Virol. 2015;89(16):8416-27.

19.Wu A, Wang Y, Zeng C, Huang X, Xu S, Su C, Wang M, Chen Y * , Guo D*. Prediction and biochemical analysis of putative cleavage sites of the 3C-like protease of Middle East respiratory syndrome coronavirus. Virus Res. 2015;208:56-65.