EDUCATION AND POSITIONS HELD:

Sc.D., Department of Epidemiology, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland, USA, 1982

Associate Professor, Graduate Institute of Public Health, National Taiwan University College of Medicine, Taiwan, 1983-1986

Professor, Graduate Institute of Public Health, National Taiwan University College of Medicine, Taiwan, 1986-1993

Director, Graduate Institute of Public Health, National Taiwan University College of Public Health, Taiwan, 1993-1994

Professor, Graduate Institute of Epidemiology, National Taiwan University College of Public Health, Taiwan, 1994-2006

Founding Director, Graduate Institute of Epidemiology, National Taiwan University College of Public Health, Taiwan, 1994-1997

Director General, Division of Life Sciences, National Science Council, Taiwan, 1997-1999

Dean, College of Public Health, National Taiwan University, Taiwan, 1999-2002

Deputy Minister, National Science Council, Taiwan, 2002-2003

Minister, Department of Health, Taiwan, 2003-2005

Distinguished Professor, Genomics Research Center, Academia Sinica, Taiwan, 2006-2015, 2020-now

Minister, National Science Council, Taiwan, 2006-2008

Vice President, Academia Sinica, Taiwan, 2011-2015

Vice President, Office of President, Taiwan, 2016-2020

Premier, Executive Yuan, Taiwan, 2023-2024

HONORS:

Outstanding Research Fellow Award, National Science Council, Taiwan, 1986-1996

Fogarty International Research Fellowship, US National Institute of Health, USA, 1989

Outstanding Teaching Award, Ministry of Education, Taiwan, 1992

Outstanding Scholar, Foundation for Outstanding Scholarship, Taiwan, 1995-1999

National Chair Professor, Ministry of Education, Taiwan, 1997-2002

Academic Award, Ministry of Education, Taiwan, 1997

Academician, Academia Sinica, Taiwan, 1998

ISI Citation Classic Award, ISI Thomas Scientific, USA, 2001

Outstanding Research Fellow Award, National Science Council, Taiwan, 2003

Health Medal (First Rank), Department of Health, Taiwan, 2005

Achievement Medal (First Rank), Executive Yuan, Taiwan, 2005

Presidential Science Prize, Office of the President, Taiwan, 2005

Member, World Academy of Sciences, Italy, 2005

Honorary Member, Mongolian Academy of Sciences, Mongolia, 2007

Cutter Lecturer on Preventive Medicine, Harvard University, USA, 2008

Dr. DV Datta Memorial Oration, National Association for the Study of the Liver, India, 2008

Officier dans l’Ordre des Palmes Academiques, Ministry of Education, France, 2009

Science and Engineering Achievement Award, Taiwanese-American Foundation, USA, 2009

Member, Delta Omega Honorary Society in Public Health, Johns Hopkins University, USA, 2010

Outstanding Merit Award, Wang Ming-Ning Memorial Foundation, Taiwan, 2010

Knight, Equestrian Order of the Holy Sepulcher of Jerusalem, Vatican, 2010

Excellence in Cancer Prevention Award, Taiwan Joint Cancer Conference, Taiwan, 2011

Prof. Vikit Viranuvatti Lecturer, Gastroenterological Association of Thailand, Thailand, 2011

Science Profession Medal (First Rank), National Science Council, Taiwan, 2012

Knowledge for the World Award, Johns Hopkins University, USA, 2012

Knight, Pontifical Equestrian Order of St. Gregory the Great, Vatican, 2013

Outstanding Achievement Award in Science and Technology, Executive Yuan, Taiwan, 2013

Prof. Juei-Low Sung Award, Asia-Pacific Primary Liver Cancer Expert Meeting, Taiwan, 2014

Honorary Doctor of Philosophy, China Medical University, Taiwan, 2014

Distinguished Service Medal (First Class), Academia Sinica, Taiwan, 2016

International Member, National Academy of Sciences, USA, 2017

Honorary Doctor of Philosophy, Kaohsiung Medical University, Taiwan, 2020

Honorary Doctor of Science, National Sun Yet-Sen University, Taiwan, 2020

Order of Dr. Sun Yat-sen with Grand Cordon, Office of the President, Taiwan, 2020

Academician, Pontifical Academy of Sciences, Vatican, 2021

Order of Propitious Clouds with Special Grand Cordon, Office of the President, Taiwan, 2024

RESEARCH INTERESTS:

Molecular and genomic epidemiology

Researches in the Chen’s lab encompass a broad spectrum of molecular and genomic epidemiology. They include:

Long-term follow-up study on the risk prediction models for hepatocellular carcinoma, cervical carcinoma, and nasopharyngeal carcinoma including biomarkers of chronic infection of hepatitis B and C virus, human papillomavirus, and Epstein-Barr virus, respectively, as well as susceptibility genotypes and lifestyle characteristics of the host;

Molecular and genomic biomarkers of health hazards caused by chronic arsenic poisoning: gene-environment interaction;

Genome-wide association study and polygenic risk scores for hepatocellular carcinoma, cervical carcinoma, nasopharyngeal carcinoma, and lung adenocarcinoma.

Assessment of the effectiveness of national programs related to cancer control in Taiwan.

我們的研究室的工作主要聚焦於分子及基因體流行病學，包括：

SELECTED PUBLICATIONS:

G. A. Kim, Y. S. Lim*, S. Han, G. H. Choi, W. M. Choi, J. Choi, D. H. Sinn, Y. H. Paik, J. H. Lee, Y. B. Lee, J. Y. Cho, N. Y. Heo, M. F. Yuen, V. W. Wong, S. L. Chan, H. I. Yang and C. J. Chen, 2024, “Viral load-based prediction of hepatocellular carcinoma risk in non-cirrhotic chronic hepatitis B patients: a multinational study for the development and external validation of a new prognostic model”, Ann Intern Med, 177(10), 1308-1318.

J. R. Jhuang, C. H. Lee, C. J. Chiang, C. J. Chen and W. C. Lee*, 2024, “Reduced burden of arsenic-related cancers after water mitigation in Taiwan”, Environ Int, 185, 108542.

G. C. Chang, C. H. Chiu, C. J. Yu, Y. C. Chang, Y. H. Chang, K. H. Hsu, Y. C. Wu, C. Y. Chen, H. H. Hsu, M. T. Wu, C. T. Yang, I. W. Chong, Y. C. Lin, T. C. Hsia, M. C. Lin, W. C. Su, C. B. Lin, K. Y. Lee, Y. F. Wei, G. Y. Lan, W. P. Chan, K. L. Wang, M. H. Wu, H. H. Tsai, C. F. Chian, R. S. Lai, J. Y. Shih, C. L. Wang, J. S. Hsu, K. C. Chen, C. K. Chen, J. Y. Hsia, C. K. Peng, E. K. Tang, C. L. Hsu, T. Y. Chou, W. C. Shen, Y. H. Tsai, C. M. Tsai, Y. M. Chen, Y. C. Lee, H. Y. Chen, S. L. Yu, C. J. Chen, Y. L. Wan, C. A. Hsiung, P. C. Yang* and TALENT Investigators, 2024, “Low-dose CT screening among never-smokers with or without a family history of lung cancer in Taiwan: a prospective cohort study”, Lancet Respir Med, 12(2), 41-152.

W. K. J. Lam, A. D. King, J. A. Miller, Z. Liu, K. J. Yu, M. L. K. Chua, B. B. Y. Ma, M. Y. Chen, B. A. Pinsky, P. J. Lou, J. K. S. Woo, W. L. Hsu, J. Simon, D. L. Doolan, T. Waterboer, E. P. Hui, H. Li, R. K. Tsang, K. C. W. Wong, J. P. Goh, A. C. Vlantis, Q. Y. Ai, L. M. Wong, V. Abdullah, J. C. Lin, C. J. Chen, R. M. Pfeiffer, Q. T. Le, A. W. M. Lee, M. Ji, S. Cao, J. Ma, A. T. C. Chan, K. C. A. Chan* and A. Hildesheim, 2023, “Recommendations for Epstein-Barr virus-based screening for nasopharyngeal cancer in high- and intermediate-risk regions”, J Natl Cancer Inst, 115(4), 355–364.

P. J. Lou, W. K. J. Lam, W. L. Hsu, R. M. Pfeiffer, K. J. Yu, C. M. L. Chan, V. C. T. Lee, T. C. Chen, S. D. Terng, Y. A. Tsou, Y. S. Leu, L. J. Liao, Y. L. Chang, Y. C. Chien, C. P. Wang, C. Y. Lin, C. H. Hua, J. C. Lee, T. L. Yang, C. H. Hsiao, M. S. Wu, M. H. Tsai, H. C. Cheng, A. Hildesheim, C. J. Chen, K. C. A. Chan*, Z. Liu and GEV-NPC Study Group, 2023, “Performance and Operational Feasibility of Epstein-Barr Virus-Based Screening for Detection of Nasopharyngeal Carcinoma: Direct Comparison of Two Alternative Approaches”, J Clin Oncol, 41(26), 4257-4266.

C. J. Chen*, 2022, “Taiwan’s pandemic vice-president: from lab bench to public office and back”, Nature, 603(7900), 203.

C. J. Chiang, J. R. Jhuang, Y. W. Yang, B. Z. Zhuang, S. L. You, W. C. Lee and C. J. Chen*, 2022, “Association of nationwide hepatitis B vaccination and antiviral therapy programs with end-stage liver disease burden in Taiwan”, JAMA Network Open, 5(7), e2222367. (SCIE)

C. J. Chen*, S. L. You, W. L. Hsu, H. I. Yang, M. H. Lee, H. C. Chen, Y. Y. Chen, J. Liu, H. H. Hu, Y. J. Lin, Y. J. Chu, Y. T. Huang, C. J. Chiang and Y. C. Chien, 2021, “Epidemiology of virus infection and human cancer”, Recent Results Cancer Res, 217, 13-45.

C. J. Chen*, 2021, “The strategy behind Taiwan’s COVID-19 immunization program: national security and global solidarity”, Taiwan Strategists, 11, 1-18.

G. Awandare*, E. André*, E. Corrales-Aguilar*, C. J. Chen*, M. A. Mostajo-Radji*, L. Jancoriene* and M. Nemer, 2020, “Science advisers around the world on 2020”, Nature, 588(7839), 586-588.

W. L. Hsu, Y. C. Chien, Y. T. Huang, K. J. Yu, J. Y. Ko, C. Y. Lin, Y. A. Tsou, Y. S. Leu, L. J. Liao, Y. L. Chang, J. Y. Su, Z. Liu, C. P. Wang, S. D. Terng, C. H. Hua, J. C. Lee, T. L. Yang, C. H. K. Hsiao, M. S. Wu, M. H. Tsai, M. J. Liu, P. J. Lou, A. Hildesheim and C. J. Chen*, 2020, “Cigarette smoking increases the risk of nasopharyngeal carcinoma through the elevated level of IgA antibody against Epstein-Barr virus capsid antigen: A mediation analysis.”, Cancer Medicine, 9(5), 1867-1876. (SCIE)

M. H. Lee, H. I. Yang, S. N. Lu, C. L. Jen, S. L. You, L. Y. Wang, C. H. Wang, W. J. Chen, C. J. Chen* and REVEAL-HCV Study Group, 2012, “Chronic hepatitis C virus infection increase mortality from hepatic and extrahepatic diseases: a community-based long-term prospective study”, J Infect Dis, 206, 469-477.

H. I. Yang, M. F. Yuen, H. L. Chan, K. H. Han, P. J. Chen, D. Y. Kim, S. H. Ahn, C. J. Chen*, V. W. Wong and W. K. Seto, 2011, “Risk estimation for hepatocellular carcinoma in chronic hepatitis B (REACH-B): development and validation of a predictive score”, Lancet Oncol, 12, 568-574.

H. C. Chen, M. Schiffman, C. Y. Lin, M. H. Pan, S. L. You, L. C. Chuang, C. Y. Hsieh, K. L. Liaw, A. W. Hsing, C. J. Chen* and CBCSP-HPV Study Group, 2011, “Persistence of type-specific human papillomavirus infection and increased long-term risk of cervical cancer”, J Natl Cancer Inst, 103, 1387-1396.

H. I. Yang, S. H. Yeh, P. J. Chen, U. H. Iloeje, C. L. Jen, L. Y. Wang, S. N. Lu, S. L. You, D. S. Chen, Y. F. Liaw, C. J. Chen* and REVEAL-HBV Group, 2008, “Association between Hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma”, J Natl Cancer I, 100, 1134-1143.

C. L. Chen, H. I. Yang, W. S. Yang, C. J. Liu, P. J. Chen, S. L. You, L. Y. Wang, C. A. Sun, S. N. Lu, D. S. Chen and C. J. Chen*, 2008, “Metabolic factors and risk of hepatocellular carcinoma by chronic hepatitis B/C virus infection: a follow-up study in Taiwan”, Gastroenterology, 135, 111-121. (SCIE)

U. H. Iloeje, H. I. Yang, J. Su, C. L. Jen, S. L. You and C. J. Chen*, 2006, “Predicting cirrhosis risk based on the level of circulating hepatitis B viral load”, Gastroenterology, 130, 678-686. (SCIE)

C. J. Chen*, H. I. Yang, J. Su, C. L. Jen, S. L. You, S. N. Lu, G. T. Huang and U. H. Iloeje, 2006, “Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level”, JAMA, 295, 65-73.

H. I. Yang, S. N. Lu, S. L. You, C. A. Sun, L. Y. Wang, K. Hsiao, P. J. Chen, D. S. Chen, Y. F. Liaw and C. J. Chen*, 2002, “Hepatitis B e antigens and the risk of hepatocellular carcinoma”, New Engl J Med, 347, 168-174. (SCIE)

Y. C. Chien, J. Y. Chen, M. Y. Liu, H. I. Yang, M. M. Hsu, C. J. Chen* and C. S. Yang, 2001, “Serologic markers of Epstein-Barr virus infection and nasopharyngeal carcinoma in Taiwanese men”, New Engl J Med, 345, 1877-1882. (SCIE)

K. H. Morales, L. Ryan*, T. L. Kuo, M. M. Wu and C. J. Chen, 2000, “Risk of internal cancers from arsenic in drinking water”, Environ Health Perspect, 108, 655-661. (SCIE)

C. J. Chen*, M. W. Yu and Y. F. Liaw, 1997, “Epidemiological characteristics and risk factors of hepatocellular carcinoma”, J Gastroenterol Hepatol, 12, S294-S308.

M. H. Chang*, C. J. Chen, M. S. Lai, M. S. Kong, T. C. Wu, D. C. Liang, H. M. Hsu, W. Y. Shau, D. S. Chen and Taiwan Childhood Hepatoma Study Group, 1997, “Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children”, New Engl J Med, 336, 1855-1859. (SCIE)

H. Y. Chiou, Y. M. Hsueh, K. F. Liaw, S. F. Horng, M. H. Chiang, Y. S. Pu, J. S. N. Lin, C. H. Huang and C. J. Chen*, 1995, “Incidence of internal cancers and ingested inorganic arsenic: A seven-year follow-up study in Taiwan”, Cancer Res, 55, 1296-1300. (SCIE)

C. J. Chen*, Y. M. Hsueh, M. S. Lai, M. P. Hsu, M. M. Wu and T. Y. Tai, 1995, “Increased prevalence of hypertension and long-term arsenic exposure”, Hypertension, 25, 53-60. (SCIE)

C. J. Chen*, C. W. Chen, M. M. Wu and T. L. Kuo, 1992, “Cancer potential in liver, lung, bladder and kidney due to ingested inorganic arsenic in drinking water”, Brit J Cancer, 66, 888-892. (SCIE)

C. J. Chen* and C. J. Wang, 1990, “Ecological correlation between arsenic level in well water and age-adjusted mortality from malignant neoplasms”, Cancer Res, 50, 5470-5474. (SCIE)

M. M. Wu, T. L. Kuo, Y. H. Hwang and C. J. Chen*, 1989, “Dose-response relation between arsenic concentration in well water and mortality from cancers and vascular diseases”, Am J Epidemiol, 130, 1123-1132. (SCIE)

C. J. Chen*, T. L. Kuo and M. M. Wu, 1988, “Arsenic and cancers (letter)”, Lancet, 1, 414-415. (SCIE)

C. J. Chen*, Y. C. Chuang, T. M. Lin and H. Y. Wu, 1985, “Malignant neoplasms among residents of a blackfoot disease-endemic area in Taiwan: High-arsenic artesian well water and cancers”, Cancer Res, 45, 5895-5899. (SCIE)

Chang, Tien-Hsien 張典顯

Chen, Chien-Jen 陳建仁

Chen, Wei 陳緯

Cheng, Wei-Chieh 鄭偉杰

Chuang, Trees-Juen 莊樹諄

Hu, Chun-Mei 胡春美

Hung, Shang-Cheng 洪上程

Hwang-Verslues, Wendy W. 黃雯華

Juan, Li-Jung 阮麗蓉

Li, Tsung-Lin 李宗璘

Lin, Kuo-I 林國儀

Lin, Su-Chang 林世昌

Lu, Joyce Jean 呂仁

Ma, Che Alex 馬徹

Shen, Chia-Ning 沈家寧

Wong, Chi-Huey 翁啟惠

Yang, Hwai-I 楊懷壹