张辉博士的科研重点是以PET和CT成像为代表的诊断成像和治疗成像技术，包括医学成像物理机制、影像链路和核心部件、成像算法等。同时，研究团队致力于推动分子影像与机器人手术、深度学习技术的结合，推动诊疗一体化的精准分子影像临床应用。
PET/CT是目前最先进的临床影像学设备之一，在肿瘤、中枢神经及心血管系统等重大疾病的临床诊治路径中发挥着不可或缺的作用。张辉研究员与北京协和医院核医学科合作，自2011年开始致力于国产高端PET/CT的研发与产业化，通过医工交叉与产学研医合作，以临床需求驱动国产PET/CT自主创新。所研发的飞行时间PET/CT产品在性能指标和临床图像质量方面均已达到或超越国际主流产品水平，首创的自由呼吸成像和无源质控等技术亦成为业界的引领性技术。目前已经获得两张NMPA医疗器械产品注册证和一张CE证书，入选第五批“优秀国产医疗设备”产品目录，并获得科技部十三五数字诊疗专项国产高端医疗设备应用示范项目支持。同时，研发的下一代PET/CT产品性能指标再次达到国际领先水平，并获得科技部十三五数字诊疗专项PET核心器件研发项目支持，在SiPM核心器件和读出电路ASIC芯片方面实现国产化，真正实现从整机到核心器件的自主可控。截至目前所研制的PET/CT产品已经在北京协和医院、北京友谊医院等各级医疗机构实现装机近20台，累计完成临床患者扫描超过5万例，得到了行业专家和医疗机构的广泛认可。
1．Preoperative prediction of pathological grade in pancreatic ductal adenocarcinoma based on 18F-FDG PET/CT radiomics. Xing H, Hao Z, Zhu W, Sun D, Ding J,
Zhang H
, Liu Y, Huo L. EJNMMI Research, 2021.11(1):19.
2．Comparison of different kinetic models for dynamic F-18-FDG PET/CT imaging of hepatocellular carcinoma with various, also dual-blood input function,Geist, Barbara Katharina; Wang, Jingnan; Wang, Xuezhu; Lin, Jianzhen; Yang, Xu;
Zhang, Hui
; Li, Fang; Zhao, Haitao; Hacker, Marcus; Huo, Li; Li, Xiang，PhysicsinMedicineandBiology,2020.65(4) :045001
3．Li Huo, Nan Li, Heyu Wu, Wenjia Zhu, Haiqun Xing, Jiantao Ba, Tong Wang, Fang Li,
Hui Zhang
*, Performance Evaluation of a New High-Sensitivity Time-of-Flight Clinical PET/CT System, EJNMMI Physics, 2018.5:29
4．Ximin Shi, Nan Li, Haiyan Ding, Yonghong Dang, Guilan Hu, Shuai Liu, Jie Cui, Yue Zhang, Fang Li,
Hui Zhang
, Li Huo*, Comparison among Reconstruction Algorithms for Quantitative Analysis of 11C-Acetate Cardiac PET Imaging, Contrast Media & Molecular Imaging, vol. 2018, Article ID 9193403, 10 pages, 2018. doi:10.1155/2018/9193403
5．Wenjia Zhu,Shaobo Yao,Haiqun Xing,
Hui Zhang
,Yuan-chuan Tai,Yingqiang Zhang,Yimin Liu,Yanru Ma,Chenxi Wu,Hongkai Wang,Zibo Li,Zhanhong Wu,Zhaohui Zhu,Fang Li,Li Huo*,Biodistribution and Radiation Dosimetry of the Enterobacteriaceae-Specific Imaging Probe [18F]Fluorodeoxysorbitol Determined by PET/CT in Healthy Human Volunteers.
Molecular Imaging and Biology
. 2016,18(5), 782-787
6．M Wang, N Guo, G Hu, G El fakhri,
H Zhang
*, Q Li*. A novel approach to assess the treatment response using Gaussian random field in PET. Medical Physics, 2016, 43(2): 833-842.（共同通讯作者）
7．Mengdie Wang, Guangshu Hu,
Hui Zhang
*. Performance comparison of dual-head PEM scanner by Monte Carlo simulation.
Nuclear Inst. and Methods in Physics Research, A
737C (2014):5-10.
8．Yilong Liu, Mengdie Wang, Jing Bai,
Hui Zhang
*. System response matrix calculation using symmetries for dual-head PET scanners.
International journal of imaging systems and technology
.23(2013):205–214.
9．Zhe Guo, Zhiwei Tang, Xinzeng Wang, Mingliang Deng, Guangshu Hu,
Hui Zhang
*. Performance Evaluation of a Modular Detector Unit forX-ray Computed Tomography.
Sensors
, 13(2013):5167-5180.
10．Zhiwei Tang, Guangshu Hu,
Hui Zhang
*.An efficient metal artifact reduction method based on improved total variation regularization.
Journal of Medical and Biological Engineering
, (2013) doi:10.5405/jmbe.1358.
11．Xin Liu, Xiaolian Guo, Fei Liu, Yi Zhang,
Hui Zhang
, Guangshu Hu, Jing Bai*. Imaging of Indocyanine Green Perfusion in Mouse Liverwith Fluorescence Diffuse Optical Tomography.
IEEE Transactions on Biomedical Engineering
. 58(2011): 2139 - 2143
12．
Hui Zhang*
, Qinan Bao, Nam T. Vu, Robert W. Silverman, Richard Taschereau, Brittany N. Berry-Pusey, Ali Douraghy, Fernando R. Rannou, David B. Stout and Arion F. Chatziioannou. Performance Evaluation of PETbox: a Low Cost Bench Top Preclinical PET Scanner.
Molecular Imaging and Biology
. 13(2011):949-961
13．Xin Liu,Xiaolian Guo,Fei Liu,Yi Zhang,
Hui Zhang
,Guangshu Hu,Jing Bai.Imaging of Indocyanine Green Perfusion in Mouse Liver With Fluorescence Diffuse Optical Tomography.
IEEE Transactions on
Biomedical Engineering
.58(2011): 2139 – 2143.
14．
Hui Zhang
, Nam T. Vu, Qinan Bao, Robert W. Silverman, Brittany N. Berry-Pusey, Ali Douraghy, Darin A. Williams, Fernando R. Rannou, David B. StoutandArion F. Chatziioannou.Performance Characteristics of BGO Detectors for a Low Cost Preclinical PET Scanner.
IEEE Transactions on Nuclear Science
.57(2010):1038-1044
