研究内容：
我们实验室以小鼠作为模式生物，主要研究方向有：
1、探索
神经系统疾病中神经元死亡的分子机制；
2、探索神经退行性疾病可能的干预机制；
我们的研究工作可以深入了解在神经系统疾病中突触结构和功能的变化以及神经细胞死亡的机制。可能为进一步干预和治疗神经系统疾病退行性疾病提供线索。
课题组网站：
1.
Shan Yao*; Min-Dong Xu; Ying Wang; Shen-Ting Zhao
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; Jin Wang; Gui-Fu Chen; Wen-Bing Chen; Jian Liu; Guo-Bin Huang; Wen-Juan Sun; Yan-Yan Zhang; Huan-Li Hou; Lei Li; Xiang-Dong Sun.
Astrocytic lactate dehydrogenase A regulates neuronal excitability and depressive-like behaviors through lactate homeostasis in mice.
NATURE COMMUNICATIONS
. Feb 2023.
3.
Hu, Jin-Xia
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*; Ma, Wei-Jing*; He, Li-Ying*; Zhang, Cong-Hui*; Zhang, Cheng; Wang, Yan; Chen, Chao-Nan; Shen, Da-Yong; Gao, Hui-Min; Guo, Rui-Ru; Ning, Qian-Qian; Ye, Xin-Chun; Cui, Gui-Yun
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; Li, Lei
#
.
Macrophage migration inhibitory factor (MIF) acetylation protects neurons from ischemic injury.
CELL DEATH & DISEASE
. 18 May 2022. 13(5).
4.
Lin, Dong*; Li, Luhui; Chen, Wen-Bing; Chen, Jiang; Ren, Dongyan; Zheng, Zhi-Heng; Zhao, Changqin; Zhong, Yanzi; Luo, Bin; Jing, Hongyang; Chen, Peng; Zou, Suqi; Lai, Xinsheng; Zhou, Tian; Ding, Ning; Li, Lei; Pan, Bing-Xing
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; Fei, Erkang
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.
LHPP, a risk factor for major depressive disorder, regulates stress-induced depression-like behaviors through its histidine phosphatase activity.
MOLECULAR PSYCHIATRY
. 02 Dec 2022.
5.
Chen, Wenbing*; Luo, Bin*; Gao, Nannan*; Li, Haiwen; Wang, Hongsheng; Li, Lei; Cui, Wanpeng; Zhang, Lei; Sun, Dong; Liu, Fang; Dong, Zhaoqi; Ren, Xiao; Zhang, Hongsheng; Su, Huabo; Xiong, Wen-Cheng; Mei, Lin
#
.
Neddylation stabilizes Na(v)1.1 to maintain interneuron excitability and prevent seizures in murine epilepsy models.
JOURNAL OF CLINICAL INVESTIGATION
. 15 Apr 2021. 131(8).
7.
Li, Lei*; Cao, Yu*; Wu, Haitao; Ye, Xinchun; Zhu, Zhihui; Xing, Guanglin; Shen, Chengyong; Barik, Arnab; Zhang, Bin; Xie, Xiaoling; Zhi, Wenbo; Gan, Lin; Su, Huabo; Xiong, Wen-Cheng; Mei, Lin
#
.
Enzymatic Activity of the Scaffold Protein Rapsyn for Synapse Formation.
NEURON
. 2016. 92(5):1007-1019.
8.
Sun, Xiang-Dong
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*; Li, Lei*; Liu, Fang; Huang, Zhi-Hui; Bean, Jonathan C.; Jiao, Hui-Feng; Barik, Arnab; Kim, Seon-Myung; Wu, Haitao; Shen, Chengyong; Tian, Yun; Lin, Thiri W.; Bates, Ryan; Sathyamurthy, Anupama; Chen, Yong-Jun; Yin, Dong-Min; Xiong, Lei; Lin, Hui-Ping; Hu, Jin-Xia; Li, Bao-Ming; Gao, Tian-Ming; Xiong, Wen-Cheng; Mei, Lin
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.
Lrp4 in astrocytes modulates glutamatergic transmission.
NATURE NEUROSCIENCE
. 2016. 19(8):1010.
14.
Zhao, Kai*; Shen, Chengyong
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; Li, Lei; Wu, Haitao; Xing, Guanglin; Dong, Zhaoqi; Jing, Hongyang; Chen, Wenbing; Zhang, Hongsheng; Tan, Zhibing; Pan, Jinxiu; Xiong, Lei; Wang, Hongsheng; Cui, Wanpeng; Sun, Xiang-Dong; Li, Shihua; Huang, Xinping; Xiong, Wen-Cheng; Mei, Lin
#
.
Sarcoglycan Alpha Mitigates Neuromuscular Junction Decline in Aged Mice by Stabilizing LRP4.
JOURNAL OF NEUROSCIENCE
. 10 Oct 2018. 38(41):8860-8873.
15.
Jiao, Hui-Feng*; Sun, Xiang-Dong; Bates, Ryan; Xiong, Lei; Zhang, Lei; Liu, Fang; Li, Lei; Zhang, Hong-Sheng; Wang, Shun-Qi; Xiong, Ming-Tao; Patel, Mihir; Stranahan, Alexis M.; Xiong, Wen-Cheng; Li, Bao-Ming
#
; Mei, Lin
#
.
Transmembrane protein 108 is required for glutamatergic transmission in dentate gyrus.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
. 2017. 114(5):1177-1182.
地址：上海市浦东新区华夏中路393号 邮编：201210; 上海市徐汇区岳阳路319号8号楼 邮编：200031（岳阳路校区）
沪公网安备 31011502006855号
Yueyang Campus: 319 Yueyang Road, Shanghai 200031; Zhangjiang Campus: 393 Middle Huaxia Road, Pudong, Shanghai, 201210
沪公网安备 31011502006855号
