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Darwin's Doubt: The Explosive Origin of Animal Life and the Case for Intelligent Design Paperback – June 3, 2014

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    5.0 out of 5 stars Stephen C. Meyer is prominent in Intelligent Design (ID) theory. He serves as Director of the Center For Science And Culture, Discovery Institute, in Seattle. A philosopher of science and former geophysicist, Meyer holds a Cambridge University Ph.D. His successful writings, including Signature In The Cell, and now this best-selling book, plus major media recurrences tag him as an ID legend in the making. Philosopher of science Robert Bishop, in his review of the book, states: “…Meyer has given what I think is the strongest argument for ID to be found anywhere.” Emeritus professor of biology Darrel Falk, in his review states, “…somewhat of a masterpiece in accomplishing their agenda,” and, “the depth of knowledge…is very impressive.” I concur with both critics.
    Darwin’s Doubt derives its name from what Meyer views as Darwin’s weightiest unresolved dilemma—the inexplicability of the Cambrian explosion. The quandary has only worsened since Darwin. Whereas Signature In The Cell addressed chemical evolution theory, Darwin’s Doubt confronts biological evolution theory. Of course, Meyer considers ID to be the inference to the best explanation of it all. In his now familiar style, he argues convincingly. Meyer approaches his thesis in three parts, with copious endnotes, and a generous bibliography. Part I retells the history of Darwin’s dilemma, and the futile efforts to resolve it. Part II details how the biologic information revolution worsened Darwin’s dilemma, while vectoring towards ID. Part III moves past Darwinian to dissect emerging theories readdressing evolution theory. Let’s proceed.

    Part One: The Mystery Of The Missing Fossils

    Darwin attempted to replace design in Nature with Nature’s own independent, uniformitarian enterprise. But, Swansea Valley Cambrian layer findings portrayed a relatively sudden injection of new species and complexity, while lacking Precambrian ancestors or transitional forms. Even worse, these sudden appearance-disappearance acts persisted through subsequent geologic history. The lack of uniformitarianism (i.e. continuity) was obvious.
    In 1909, paleontologist Charles Walcott discovered in British Columbia the Burgess Shale equivalent to Swansea Valley. Abundant, well-preserved hard and soft body parts further inflamed the controversy. 20 of 26 known animal phyla suddenly appeared in the Cambrian strata. Walcott, a Darwinian, failed to conclusively explain the top-down versus bottom-up findings; instead confirming and expounding upon the Swansea Valley revelations.
    In 1980, Chinese scientists uncovered Chengjiang’s Maotianshan Shale. Beautifully preserved Cambrian-era fossils were even more plentiful and confirming. The disputation of Walcott’s artifact hypothesis, built on absent soft body preservations, was complete. The lack of transitional forms in three widely displaced worldwide sites was disconcerting to Darwinism.
    Attempts have been made to link the Precambrian Ediacaran and Vendian layer fossils to Cambrian species, to refute sudden novelty. However, this is not the predominant opinion among paleontologists, for several firm reasons. The number of identified phyla in the Cambrian layer increased to 23 with only four of them having any possibility of a Precambrian link.
    In Chapter 5, we are introduced to “molecular clocks,” retrospective genetic studies attempting to project into early Precambrian period for a common ancestry of Cambrian phyla (i.e. “deep divergence”). One big problem: scientists know that molecular clocks are grossly unreliable. Depending on assumptions, projected epochs span from pre-Big Bang to post-Cambrian.
    Molecule-based animal phylogenetic trees contradict each other, according to which reference genes are employed. When cross-compared to taxonomic trees, there is more conflict. When taxonomic trees are compared against each other, there is yet more disagreement. The issues are severe enough that scientists risk hallowed common descent in championing “convergent evolution” from separate lines of traits. Why so much difficulty? Apparently, it is due to the repeated attempt to build trees of life against the evidence, rather than in support of it.
    Perhaps you might better recognize “punk eek” as the “punctuated equilibrium” of evolutionists Gould and Eldridge. They attempted to explain missing transitional forms by a turbo-charged evolutionary process outpacing fossilization. Meyer does an excellent job of pointing out, with references, why their theory cannot solve the Cambrian explosion mystery: lack of species selection and bottom-up evidence, but most importantly an adequate source of genetic information.
    In his review of this section, paleontologist Ralph Stearley thinks that Meyer was a bit too conservative in dating the Cambrian explosion, “glossing over” evidence that would substantially expand the period, to almost five times the estimate. Philosopher of science Paul Nelson corrects Stearley by pointing out, “Meyer himself explains, that expanding the geologic period…does little to solve the relevant problems…” Paleontologist Charles Marshall is equally quick to argue a similar objection as Stearley. However, elsewhere Meyer adequately addresses his charge. I agree that even the suggested expansion is too brief to improve the evolutionary appearance of body plans, and Meyer does provide the information to reach such a conclusion.

    Part Two: How To Build An Animal

    I really appreciated Meyer’s decision to follow the prior section of refutations clearing the path for the reality of the Cambrian explosion, with one now devoted to explaining “how” it might have happened. For this we can thank the progress of genetic research—DNA’s chemical importance in generating the biology of phylogenies. It helps even more to have already covered the introduction to all of this in Signature In The Cell. Meyer shows us that to achieve explosion of new species in the Cambrian period, we need novel genetic information for novel proteins, novel cell types, novel tissues, novel organs, and novel body plans. Nonexistence must suddenly exist. Genetic information has specified complexity, so there must have been an “information explosion.”
    Deep diving into ID inevitably encounters the fallout from the historical 1966 Wistar Conference, a turning point for evolution theory. We rehash MIT mathematician Murray Eden’s provocative exposure of mutations as actually detrimental to proteins, rather than of any advantageous benefit to them. Meyer reveals how “combinatorial inflation” of developing proteins presents an insurmountable functional protein challenge to neo-Darwinism. He recruits another MIT standout, molecular biologist Robert Sauer, to demonstrate that the limited period of the Cambrian explosion did not provide enough opportunity for even a single new functional protein construction by natural processes (i.e. Darwinian mutations).
    A Douglas Axe story is always fascinating. The molecular biologist borrowed from Sauer’s research, expanding on it with potential mutagenesis risk to protein folding. His result distances Darwinian mutations far from the real world of protein biology and the Cambrian explosion.
    In Chapter 11, Meyer reveals why homologous gene speculations can be deceptive. It begins with the premise—common ancestry. Wearing such blinders, scientists invest various mutational possibilities in theorizing how the purported homologous genes came to be. Not only is no other source considered (i.e. ID), but obvious specified complex information is ignored. Non-homologous genes (ORFans) are simply relegated to chance. Theories fail to account for functional protein folding, specified complex information, and the improbability of mutations leading to functional proteins. Robert Bishop takes exception here as well. He sees all of this as “question-shift strategy,” switching between the results of common ancestry and origin of life (OOL) considerations, thereby misrepresenting the literature. Paul Nelson takes up the gauntlet to defend Meyer. He states that Bishop is “just flatly mistaken,” noting that this book is about the origin of body plans, at most only a “tenuous connection” to OOL. From all I read it seems that Nelson has the proper perspective here.

    Chapter 12: Complex Adaptations and the Neo-Darwinian Math

    A nice thought among evolutionary biologists is that new species beneficial mutations might arise from several coordinated mutations. These “complex adaptations” could occur if a species is given enough time for large enough gene pool populations to form these multi-mutation traits. Basically, it is an attempt to overcome improbability statistics by overwhelming the chances of occurrence with excessive randomness. Unfortunately, as demonstrated by Michael Behe, David Snoke, and supported even by their naysayers, the most liberally allowed necessary historical factors fall far short of the requirement. And, that is only when taking into consideration just two such coordinated mutations, far short of any realistic demand for the Cambrian explosion. Douglas Axe and Ann Gauger worked in the laboratory to genetically alter a bacterial enzyme into another functional relative, and discovered that at minimum, seven of these coordinated mutations were required to foster a single event’s complex adaptation. Unfortunately, Axe’s calculated natural upper boundary limits Nature to only six coordinated mutations—since the advent of life! Bottom line, Darwinian evolution producing complex adaptations is off the table for any serious consideration. Darrel Falk disagrees on the research implications, rather viewing the counterarguments as simply Meyer attempting to construct his justification for external intelligence only. Future research should benefit one or the other of them.

    Chapter 13: The Origin of Body Plans

    Not so willing to easily give up, researchers proposed moving up the occurrence of mutations to much earlier in embryonic development. The idea is that given enough time, impacting enough cell differentiation, larger-scale change might occur, at least enough to yield altered functional body plans. Unfortunately, it turns out that it isn’t so simple as that. Earlier developmental mutations invoke many other necessary coordinated changes, and the embryo is not friendly to such early alterations, raging in a fit of autoimmune hostility. Classic experiments in Drosophila species (fruit flies) with “saturation mutagenesis” were inevitably fatal early on. Developmental gene regulatory networks (dGRNs), basically a circuit board of signaling molecules, are responsible for ensuring healthy embryonic development. When mutations interfere with the complex coordinated molecular circuitry, it spells disaster for the nascent organism. So, here’s the rub—the early-on coordinated mutations necessary to new body plans are systematically erased, while the later developmental spontaneous mutations, even if non-deleterious, are too late in the progression of embryonic events to have any reasonable chance of effecting new body plans. Critic Falk admits that, “We really have little idea at this point how things would have worked…” However, he isn’t so willing to forego the search quite yet. Charles Marshall counters Meyer by proposing that ancient dGRNs were much simpler than today’s, therefore not as prone to deleterious mutation effects. Meyer rebuts, adhering to the evidence already laid out. The real problem here is that this is pure speculation on Marshall’s part, while Meyer offers evidence. Critic Marshall also purports the idea that the Cambrian explosion did not require a plethora of novel genetic information and protein folds, but only some rewiring of existing GRNs. Meyer provides an extensive rebuttal to this charge that is already laid out in the book, basically that complex organisms “would not have just required new Hox genes, ORFan genes, or genes for building new regulatory (DNA-binding) proteins…would need to produce a whole range of different proteins…”

    Chapter 14: The Epigenetic Revolution

    This is a chapter you will not want to skip over. DNA, despite its phenomenal information workload, isn’t the only major player in the game of life when it comes to forming body plans. Besides the almost unfathomably confusing intracellular interplay in specified complexity of DNA-derived, information-laden proteins of all types, even more specified complexity in biological information processing occurs at advancing levels of various cells, tissues, organs and composite body plan levels. Epigenetic information, i.e. specified complex information beyond the genes, is turning Darwinian evolutionary biology upside down by directing intracellular events beyond DNA’s direct influence. Meyer provides several fascinating examples of a wide-open field for new research, but not for evolutionists who were putting all their chips into the DNA basket.

    Part Three: After Darwin, What?

    Chapters 15 & 16: Post-Darwinian Models

    Unsurprisingly, despite the overwhelming evidence against them, evolutionists are not so easily willing to through in the towel. Within their own ranks, new theories taking exception to Darwinian evolution repeatedly emerge, attempting to take into account the contrary revelations. These “post Darwinian” proposals remain aloof from inferences to intelligent causation, despite foregoing random mutations, natural selection, or inheritance of their purported benefits. One alternative receiving quite a bit of attention is “self organization.” Stuart Kauffman’s self-organization theory opts for Nature’s spontaneous production of new body plans by taking advantage of undefined “natural laws.” Stuart Newman’s idea of self-organization is “dynamical patterning modules,” including complex molecular toolkit arrays facilitating new development and organization. Beyond limited cell clustering, he runs out of reasonable proposals. Self-organization theories are interesting, but Meyers reminds us that they fail to answer to the origin of complex specified information needs.
    Another attention-grabbing effort in the post-Darwinian milieu is “evolutionary developmental biology,” or “evo-devo” (catchy phrases must entertain when Darwinism no longer can). Scientists in Evo-devo are no longer championing the classic small-scale stuff of neo-Darwinism. Evo-devo goes after large-scale mutations hopefully far more influential in regulating new body plans. Unfortunately, the results of evo-devo remain at small-scale levels. The favored regulatory Hox genes fail on several accounts. Bishop doesn’t agree with Meyer’s contention that neo-Darwinism is being abandoned, rather he sees Evo-devo as simply building upon it towards a “new synthesis” in evolution theory. Ralph Stearley agrees with Bishop. Nelson disagrees with them, insisting that evo-devo is not about the business of applying band-aids to neo-Darwinism theory, but instead developing core dogma replacements. Meyer’s emphasis aligns with Nelson’s thoughts.
    “Neutral evolution” focuses on the gradual accumulation of random mutations eventually leading to new body plans, thereby lessening the role of natural selection. Somewhat of a rehash of old ideas, it fails to account for the necessary enduring management of any accumulating mutated genes during the interim. Also, what is a body plan to do with even potentially beneficial mutations in the eons prior to their final needed service?
    “Neo-Lamarckism” has given old Lamarckian ideas sort of a revival by taking advantage of the epigenome phenomenon to point beyond mutations to thoughts of heritable traits. So far their offered examples are too limited, and not enduring.
    “Natural genetic engineering” proposes a built-in inheritable capacity for self-engineering of new body plans. But, coming up with adequate evidence of this pre-programmed potential is left wanting.

    Chapter 17: The Possibility of Intelligent Design

    Nelson, in afterthought of the preceding nine chapters, believes that Meyer has convincingly shown that the arguments “…either fail to address the problem of the origin of necessary biological information” or, “they simply presuppose earlier unexplained sources of such information.” After exhausting Darwinian, neo-Darwinian, and post-Darwinian challenges, Meyer brings ID up to the plate. Taking up where he left off with Signature In The Cell, Meyer invokes true design, not just apparent design, into biological development. The only accounting for specified complexity in developmental information is an intelligent designer, as with all else known that possesses specified complexity. While not denying changes over time, or even the possibility of some degree of common ancestry, Meyer close the door on chance with new body plans. Reminiscent of Signature In The Cell, Meyer reminds us that design theory has a scientific history, and remains the inference to the best explanation, which also has a standing history in science.
    Here, Falk joins Bishop in taking exception with Meyer. He sees such thoughts as “a stretch,” mainly because of what he views as ID’s paltry prediction record. Perhaps a little patience is in order. After all, the current ID movement has been around only a couple of decades, and is already producing successful prediction, while Darwinian-influenced evolution theory has held center stage for over 150 years. Surprisingly, Bishop seems to miss Meyer’s whole thesis when he states that, “…the diversification of body plans in the Cambrian never was Meyer’s target; the real target…the origin of life.” Having dealt with chemical evolution in Signature in the Cell, and now addressing biological evolution, Meyer’s grand scheme of refutation and theorizing exceeds OOL.

    Chapter 18: Signs of Design in the Cambrian Explosion

    Even evolutionary biologists agree that the Cambrian epoch events are unprecedented and unrepeated in history, and remain at a loss to explain them. ID theorists put forward both negative and positive arguments in confidence that the ID explanation is the correct one. Only ID is able to adequately account for the top-down evidence of the Cambrian explosion. While evolutionary biologists describe homologous genes across wide variations in species, but are unable to adequately account for them, ID theory accepts the repetitive aspect of genetic engineering as logical. Only ID can account for the functional specified complexity of information and true design in and beyond the genes of successful new body plans.
    Again, Bishop employs his “question-shift strategy” objection against Meyers, accusing him of using the term “de novo” to sway thoughts towards OOL. But the critique seems trivial when Bishop admits that Meyer’s referenced authors used the same term to reference something not in an OOL context. Also, Bishop attempts to label Meyer’s use of human analogies in his ontological insinuations of DNA intelligence as “the fallacy of false analogy.” Granted, more needs to be argued in this regard by Meyer, but in my opinion he has already highlighted plenty of supporting analytical and empirical evidence in his favor in both books, progressing his arguments in the direction of closure.

    Chapters 19 & 20: The Rules of Science and What’s at Stake

    Meyer claims that there is nothing non-scientific about ID theory. It meets the established rules of proper modern science theorizing and research. Its inherent predictive capability is evident in the successful ENCODE project. ID theorists are not a proponent for the “who” of ID, only the evidentiary “how” of it all. Attempts at staying ID theory with demarcation criteria fail. The ambiguousness of demarcation criteria is justifiably rejected in the philosophy of science. ID is science.
    Darwin’s Doubt has laid down the gauntlet, taking exception with neo-Darwinism’s denial of design and its failed hypotheses. Meyer has revealed its inability to successfully retrieve functional proteins form combinatorial sequence space. He has exposed the insurmountable improbability of randomness in generating new specified complex information. And he has convincingly shown neo-Darwinism’s impotence in producing novel body plans from early embryonic developmental mutations, as well as late ones. Neo-Darwinism’s fixation on genes renders it not even at the offering table for theories on generating epigenetic specified complex information. Even Stearley seems to agree to some degree: “I think he [Meyer] has developed a case for the inadequacy of standard “bean-bag” genetic approaches to the production of animal body plans.” And, the ENCODE project confirms ID’s prediction that junk DNA isn’t junk at all. Despite all this, as mentioned earlier, Bishop takes exception with Meyer’s claim that neo-Darwinian theory is being reconsidered. However, Falk does not agree with Bishop here. He sees it as, “…a fairly accurate summary of the state of biology.” After reviewing Meyer’s evidence, I am convinced that Falk is justified in his reaction, while Bishop remains wishful (see more comments of Falk in the footnote).
    ID is science, not religion. It does not deny God, but does not attempt to confirm Him either. And, despite theologian and philosopher Alister McGrath’s and Marshall’s worn out contention of ID purporting “God of the Gaps,” ID theory does not gap fill what isn’t known, but instead reveals design in what has been discovered. Elsewhere, Meyer provides an extended rebuttal to this accusation.

    Meyer has struck a grand slam homerun, first with Signature In The Cell, and now with Darwin’s Doubt. If present to read Meyer’s book today, even Darwin might no longer be in doubt. After reading his well thought out and exceptionally well-organized books, if one is not at least impressed with ID’s scientific challenge, then the blinders need to come off. Darwin’s Doubt has gone beyond Signature In The Cell to add ID biological development to ID chemical development as noteworthy components of overall ID theory. I found the book to be comfortably readable, and because of its important details, I highly recommend it to everyone in science and theology, especially evolutionary biology and liberal theology. But, every science student, from high school through collegiate levels, can benefit from this book, or suffer from missing it. Buy it and enjoy it.

    References, citations on file.
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    If you have an inquisitive mind, you will probably have noticed you learnt as much--if not more--about a topic by examining what its critics had to say, and not only its supporters. And you will doubtless have had occasion to either become agnostic, or to adopt a contrary position to what may be portrayed as orthodoxy.

    What Meyer's book is *not* about is pushing religion. In the first two parts, and the first two chapters of the third (16 of 20 chapters in all), he looks at the orthodox view of evolution, which he reports accurately. I speak as someone with a degree in zoology and a little research experience in the subject; so whilst I don't claim to be an expert, I know enough to know he's not distorting anything. At the same time, his aim is to show that orthodoxy does not explain the evidence of the fossil record with respect to the Cambrian period, nor how so many new body plans could have arisen in such a comparatively short time, with no readily identifiable pre-Cambrian precursors.

    He's not alone in this view, even amongst non-ID-supporting scientists. In fact, in Chapters 15 and 16, he examines alternatives to standard neo-Darwinism (or the New Synthesis if you prefer) being put forward by them as we speak. And generally, throughout the book, you will find copious references to the literature, as well as amplifying footnotes at the end of the book. Check out the references; chase up the bios of the chemists, biochemists, geneticists, paleontologists, geologists, etc. who in various ways and degrees challenge an orthodoxy that is frequently put across to the public as completely settled, completely unquestionable truth. I've done quite a lot of such checking, and I can report that many of them are hardly great fans of ID.

    It's a fascinating read, and I hope that open-minded people will welcome a single tome that tells them so much about orthodox views, and at the same time offers evidence why the explanatory power of those might be open to question. It's evidence I personally find persuasive, whilst I accept others might not; but even so, if one has an open mind, it should be found engaging. All the more so if one isn't overly familiar with the subject of evolution: because it covers a great deal of ground in a pretty accessible way. It's quite an education, and I'm speaking as a trained and qualified (recently retired) educator. I learnt an appreciable amount that I didn't already know, and it clarified my understanding on a number of specific scientific points.

    If you don't want to read about ID, fair enough: simply ignore the last 4 chapters, which is the only place he explicitly deals with it. He thinks ID explains what neo-Darwinism, and those other competing, but non-ID theories I alluded to earlier, can't. He may be right or wrong about that, but that has no bearing on the previous 16 chapters where he's demonstrated the severe shortcomings of neo-Darwinism in explaining the Cambrian explosion, during which the majority of phyletic body plans still extant today seem to have arisen: something that is absolutely contrary to orthodoxy, where body plans should have gradually appeared through time.

    We should find evidence for a single tree of life (with an ultimate single ancestor in the first single-celled life form on earth, appearing maybe 3.8 billion years ago, well before the Cambrian began around 500 mya). However, what we actually find in the case of animals is what appears to be an "orchard", with separate animal lineages diversifying ever since the Cambrian. Top-down rather than bottom up: complex plans appearing early, not late.

    It's true that there were a few body plans of multicellular organisms extant before the Cambrian in the pre-Cambrian (including the extinct Ediacaran fauna), and that one of those, that of the sponges, still persists to this day. But one can find nothing in the pre-Cambrian that is an obvious precursor of trilobites (early arthropods) or any of the other new body plans that emerged in the Cambrian (around 20 of them, still around today, including the Chordates to which humans belong--amongst a total of around 25-35 depending on the classificatory system applied).

    It stretches credulity beyond breaking point to postulate that precursors in the pre-Cambrian were soft-bodied and hence not fossilised, when in fact soft-tissue preservation in both the pre-Cambrian and Cambrian is readily demonstrable. It stretches credulity to think that we haven't yet found precursors but one day will, when statistical analysis of the fossil record shows it's extremely unlikely we would have missed *all* such evidence.

    The new Cambrian body plans must have come from somewhere, unless your idea is of an intelligence that can magic up something from nothing, but Meyer doesn't deny the possibility of common descent, and certainly not the reality of evolution in the sense of change over time. He fully accepts that the earth is billions of years old, and, one might wrily argue, that the fossil record means what it actually says: that neo-Darwinian gradualism doesn't occur at the macro-evolutionary level (e.g. the formation of new body plans), even if it might occur at the micro-evolutionary level (e.g. low-level species divergence within a genus). He doesn't even deny that random mutation and natural selection have a role to play at the micro-evolutionary level.

    Meyer gives a very good introduction to the concept of Shannon information and how that contrasts with functional, or specified, information. Put simply, any random combination of, say, fifty alphabetic characters is as likely, and contains as much information, as any other. But only a very few would spell out a recognisable English sentence. Vanishingly few from the 26^50 (approx. 5.6 x 10^70) combinations would do so. The issue is enormously amplified when one considers a modest protein containing 150 amino acids, for which any of 20^150 (approx. 1.4 x 10^195) combinations are possible, but for which a vanishingly small proportion have been demonstrated to be likely to be of functional use to organisms.

    Neo-Darwinists will insist that it isn't only random mutation that is involved in evolution, but crucially, natural selection. But before the latter can select for a mutation, it has to have occurred, and most mutations are likely to be harmful than beneficial. The problem gets even worse when it is realised that innovations may require a number of proteins to act in a coordinated fashion. These are the kinds of facts that are addressed in "post-Darwinistic", non-ID theories (such as evo-devo and self-organisation, neo-Lamarckism, neutral theories and natural genetic engineering) discussed in chapters 14 and 15, and I have to agree with Meyer, they aren't convincing either.

    If there's one key theme throughout the first 16 chapters, it's to do with where *new* information comes from as organisms evolve over time. An enormous amount of specified information is required to change a putative pre-Cambrian precursor into a Cambrian one. Information, for example in the case of a trilobyte, enabling the formation of the complex arthropod exoskeleton and its accompanying muscles and ligaments, not to mention the appearance of complex compound eyes. The Cambrian predator, Anomalocaris ("strange shrimp"), up to a metre or so long, had very advanced compound eyes, only exceeded in complexity by present-day dragonflies. We even find primitive jawless fish (ancestors of lampreys) appearing in the Cambrian.

    It's all quite astonishing and I can't for the life of me see how anyone would prefer to stick with the one theory that can't possibly explain it. I don't know what *does* explain it, but I have to hand it to Meyer, nothing currently explains it better than a postulate of intelligent input of some sort. He probably believes that is the Christian God, but by no means all ID proponents do. I even know of some people who are atheists who think that intelligence may in some sense be inherent in nature in everything from atoms to stars and galaxies to organisms. Maybe some non-ID explanation will eventually be forthcoming that better explains it, but for the moment, ID's at least worth consideration.

    Darwin's Doubt is a fascinating read, and for its content alone, it's worth 5 stars. However, it is not entirely without fault, because in places it seems somewhat repetitive and in need of tighter editing, which might have reduced its size appreciably. So overall, I'll give it 4 stars along with a recommendation for any independent-minded person to read it. Don't pay a lick of attention to 1-star reviews from ideological neo-Darwinists who obviously can't bring themselves to read it, yet nonetheless feel it's okay to carpet-bomb the Web with their ill-informed comments. They have little integrity and even less good manners.
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    Meyer has written a groundbreaking classic. The weight of the science stands on its own merit, regardless of associations or origins. Like his nemesis Donald Prothero, Meyer has produced exquisite science, but unlike Prothero, he has produced it without recourse to adversarial language. The downside of this is that Meyer's work is weighty with words and evidence. It should have been made easier for non-experts to read: I had to work hard to be sure I'd understood it (as did even Amazon's highest-starred reviewer, Prof David Snoke). And it might even slip past people's awareness that Meyer fully supports the notion of evolution over millions of years. It is simply a key detail of evolution with which Meyer has issue, but it is a detail seen by many scientists in many relevant areas of research.

    "Darwin's Doubt" takes its name from the one area of evolutionary theory in which Darwin himself expressed doubts - what is known in geology as the Cambrian Explosion. What geology shows is that after billions of years in which only sponge and single-cell fossils are found, representatives of nearly all the main groups (phyla) of animals suddenly appear, in a geological "explosion" of essentially five million years. This is a simplified picture but Meyer deals with anomalous details, like the fascinating Ediacaran fossils, without losing the overall perspective.

    Meyer shows that the current evidence, while supporting evolution in principle, is totally ranged against the accepted modus operandi of Natural Selection. Damning evidence arises again and again, as the findings of statistical probability are applied to many different areas of evolution research. The official science has generally slid over these feasibility challenges; there has been little checking of statistical probabilities. Evolution "happens". Sure, all the evidence shows it happens. The issue is the modus operandi, the mechanism.

    Meyer goes into the question of the likelihood of the selection of helpful mutations in enormous detail, mainly but not entirely working at the chemical molecular level, and with consistent support from the findings of other scientists, including many who are not ID fans. What Meyer draws together from all the cutting-edge research, and from quoting others' estimates of statistical probabilities, is that the probability of "natural selection" of favourable mutations to the point of new species creation is vanishingly small in practice, in any natural process of evolution.

    Chapters 9 and 10, devoted to the issues of mathematical probability, must be understood in order to grasp this failure of Evolution's presumed modus operandi. It is the failure to estimate statistical probability that has enabled evolutionists who believe in Natural Selection to continue, in all areas of evolution, to make claims which assume the workings of chance mutations in chemical processes. Meyer demonstrates again and again that the statistics of probability show that mechanistic Natural Selection is impossible even over a timescale of millions of years. It is only in the light of such vanishingly small likelihoods, demonstrated at all the cutting edges of evolution research (and which a growing number of scientists acknowledge) that Meyer finally suggests that we could consider whether a hypothesis of "intelligent design" could actually help Science begin to grapple legitimately with an otherwise intractable mystery.

    It is clear that many scientists privately support such an approach. David Snoke actually quotes what would appear to be a typical example of the many US scientists who would like to speak out openly, if they were not in fear of their academic lives being cut short, if it were to become known that they supported, or even simply expressed desire to explore, the theory of "intelligent design". It is a shame that many who are rightfully critical of "young earth" Creationism conflate those claims with the very different claims of Intelligent Design. It is a shame that Meyer's pure science here, which has not the slightest hint of either ad hom or of slanting the balance of evidence, should be conflated with the work of activists. Meyer's work stands on its own merit, whatever the funding and whatever the attitudes of others who support him. Given the history, it is understandable, but still a crying shame that such conflation has reached screaming pitch in the US, and that this has seriously compromised freedom of speech in the context of academic science - and is now seriously preventing Evolution Science from advancing.

    Meyer's hypothesis does not limit the freedom of scientists to do research. Rather, it gives them wider resources on which to draw for further investigations. Thankfully, there is a growing number of scientists, many of firstrate calibre and qualifications, but still mainly outside the accepted halls of Science, who are working with phenomena which simply do not fit the current scientific laws of reality. This all looks like good scientific potential. But it does present a big challenge to those who believe that all scientific hypotheses, and even Scientific Method, have to exclude supersensible levels of reality. For there is nothing in the essence of Scientific Method which precludes its application to supersensible levels of reality.

    The scientific and statistical evidence Meyer puts forward stands on its own merit, and should therefore not be associated with any "fundamentalist Christian" takeover threat. It is perfectly feasible to separate the issues - as should always be the case. I say, Dismantle the current evolutionists' Berlin Wall! Meyer has provided the cool mathematical evidence that openness to higher realities than what the materialistic explanation of Evolution allows, is now needed, for the sake of Evolution and indeed Science itself.

    I have again subtly rewritten my review, to further separate the pure science from the activism on all sides. It now provides slightly clearer answers to the many points commenters have made. But I cannot make anyone read me more carefully if they have already closed their mind. Yet the science cannot advance until the shouting/repressing stops ON ALL SIDES!!!!!! (!) Shouting/repressing usually betrays insecurity: is fundamentalist Christianity inadequate on scientific truth, and fundamentalist Science inadequate on evidence for God? Why not work to build bridges and start mending past inadequacies and faults?

    Both Science and Christianity are essentially and ideally about truth, despite the failings of both in practice. But only Christianity has built into it the pursuit of both Love and Truth as "moral imperatives". It should therefore fall to Christians to take up the work of reconciliation, which has to listen to the other side, listening for their truths however partial, listening for the emotional roots of grievances. I haven't been able to do complete justice in this respect to my commenters. It has been hard work to try to winnow any just grievances from the bombardment, wearisome repetition, simple irrelevance, and subtly ad-hom comments that have nothing to do with Meyer's science. But I've done what I could and hereby put out the request for more attention to this in future.
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    Jonathan Green
    5.0 out of 5 stars It has taken me quite a long time to read this book (all 413 pages, excluding reference material), but it was worth the perseverance! Not because the book was badly written, on the contrary, I found it superbly written - and very stimulating... The perseverance was associated with looking up the substantial amount of notes, bibliography and other allied documentation.

    Somewhat like his previous book, `Signature in the Cell', Stephen Meyer has presented us with a `milestone' book i.e. one which, in my opinion, substantially places `Intelligent Design' on the scientific `map'.

    The book is very well set out; in three main parts, with a logical series of chapters making up each part.

    Part one - "The Mystery of the Missing Fossils"

    Stephen Meyer gives a good historical background to Charles Darwin's book, `On the Origin of Species'; he even calls it a "singular achievement"..., but he swiftly moves on to describe the main problem facing Darwin's hypothesis, namely, the `Cambrian Explosion'.
    Meyer also spends time introducing contemporaries of Darwin, such as Agassiz and Sedgwick (both of whom were, respectfully, leading palaeontologist and geologist of the day). They had serious doubts about Darwin's proposition of the abrupt appearance of the Cambrian creatures. Darwin proposed that the geological record was "a history of the world imperfectly kept" rather than anything seriously wrong with his theory, but Agassiz and Sedgwick would have none of it.

    As expected, the Burgess Shale is given its own chapter, with good historical coverage of Charles Doolittle Walcott, the discoverer, also director of the Smithsonian Institution. Sketches of the fossilised creatures are excellent, with good explanations about morphological diversity and various family trees.

    There is a very good chapter dealing with `punctuated equilibrium', the proposal by Eldredge and Gould to explain the systematic `gaps' in the fossil record, where, according to neo-Darwinian theory, there ought to be a continuum of transitional forms leading from one body plan to another.
    Meyer explains fully why "punk eek" fails as an explanatory proposal for the origin of complex creatures found within the fossil record.

    All of the supportive diagrammatic sketches that Meyer includes, within his text, are superbly produced and very easy to understand. This applies throughout the book.

    Part two - "How to Build an Animal"

    This part is principally about biological information, and in this respect, there is an overlap with Stephen Meyer's first book `Signature in the Cell.'
    There is a short explanation of Shannon information, and how this differs from functional information (or specified information) found in living organisms.

    Meyer waxes lyrical about the contribution made by Murray Eden in respect of the "Mathematical Challenges to the Neo-Darwinian Interpretation of Evolution". Murray had pointed out that "the combinatorial space corresponding to an average-length protein"... is about 10 to the power 325 "possible amino-acid arrangements. Did the mutation and selection mechanism have enough time - since the beginning of the universe itself - to generate even a small fraction of the total number of possible amino-acid sequences corresponding to a single functional protein of that length? For Eden, the answer was clearly no." This was in the 1960's - but according to Meyer, the `mathematical challenge' has been an issue that has not been satisfactorily resolved ever since. He spends a substantial amount of space justifying this position through the work of Douglas Axe, who in the late 1980s examined the then accepted work of Richard Dawkins in his book The Blind Watchmaker, in which Dawkins used a computer programme to illustrate how natural selection could "generate the Shakespearean phrase: "Me thinks it is like a weasel.""
    Intelligence was found to pervade this kind of `evidence' to prop up the Neo-Darwinian model...

    Meyer goes on to build on his case that the mathematical challenges have remained un-bridged throughout "the various experiments and calculations performed between 2004 and 2011." Although Meyer makes a substantial case here, he is too reliant upon the work of too few specialists, in my opinion.

    Meyer's section on "Developmental Gene Regulatory Networks" was particularly interesting - and helped to introduce even greater complexity issues in the origin of body plans etc... Likewise, the section on "the Epigenetic Revolution."

    Part three - "After Darwin, What?"

    In this final section, Meyer takes on the post-Darwinian world - and theories of self-organisation, such as the work of Stuart Kauffman and Stuart Newman.
    Cutting to the chase, Meyer pus it like this: "what needs to be explained in living systems is not mainly order in the sense of simple repetitive or geometric patterns. Instead, what requires explanation is the adaptive complexity and the information, genetic and epigenetic, necessary to build it." (pg. 305). He makes a strong case in justifying this statement!
    In like manner, Meyer presents a robust summary of his issues with "evo-devo" and "Lamarckian mechanisms."

    All of the foregoing builds a strong case to support his final four chapters:
    "The Possibility of Intelligent Design", "Signs of Design in the Cambrian Explosion", "The Rules of Science" and finally "What's at Stake"....

    Meyer spends some time telling "My Story", which explains his initial interest in intelligent design through to holding robust scientific reasons for his belief in "indicators that make intelligent design scientifically detectable from the evidence of the living world."

    All in all, this book is far from some form of simplistic `biblical creationism', as suggested by other reviewers, but, in my view, a logically and soundly argued piece of scientific research, which draws conclusions toward an `inference to the best explanation.'

    Coupled with his former book `Signature in the Cell', Meyer makes the strongest case yet for `intelligent design' - and places it squarely within the scientific domain. To reject it as pseudo-science would be blind prejudice - and damaging to science in the long term, simply because ID makes testable predictions. Examples of these are given in this section!

    This is how Meyer concludes his book: "The theory of intelligent design is not based upon religious belief, nor does it provide a proof for the existence of God. But it does have faith-affirming implications precisely because it suggests the design we observe in the natural world is real, just as a traditional theistic view of the world would lead us to expect. Of course, that by itself is not a reason to accept the theory. But having accepted it for other reasons, it may be a reason to find it important."

    In other respects, the book has been beautifully produced by HarperOne, is superbly illustrated and documented - with some nice colour plates of fossils to boot!

    I heartily recommend this excellent book!!
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    AmazonUserFromCanada123
    5.0 out of 5 stars I have never heard of Stephen C Meyer until this year. The logical and scientific voice for intelligent design I have been looking for. He explains things in a logical and scientific manner that can't be denied. Darwin did not have access to this kind of data in his lifetime. The genetic code, yes code, is vastly superior and far more complicated to computer code. Code requires a designer and code has a purpose.
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